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The differences in SARS-CoV and SARS-CoV-2 specific co-expression network mediated biological process in human gut enterocytes.
Nayak, Tilak; De, Debjit; Dhal, Paltu Kumar.
  • Nayak T; Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700032, India.
  • De D; Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700032, India.
  • Dhal PK; Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700032, India. Electronic address: paltuk.dhal@jadavpuruniversity.in.
Infect Genet Evol ; 92: 104892, 2021 08.
Article in English | MEDLINE | ID: covidwho-1213429
ABSTRACT
Novel coronavirus SARS-CoV-2 was recently outbreak worldwide causes severe acute respiratory syndrome along with gastrointestinal symptoms for some infected patients. Information on detail pathogenesis, host immune responses and responsible biological pathways are limited. Therefore, infection specific host gut responses and dietary supplements to neutralize immune inflammation demand extensive research. This study aimed to find differences in global co-expression protein-protein interaction sub-network and enriched biological processes in SARS-CoV and SARS-CoV-2 infected gut enterocytes cell line. Attempts have also been made to predict some dietary supplements to boost human health. The SARS-CoV and SARS-CoV-2 infected differential express proteins were integrated with the human protein interaction network and co-expression subnetworks were constructed. Common hubs of these sub-networks reshape central cellular pathways of metabolic processes, lipid localization, hypoxia response to decrease oxygen level and transport of bio-molecules. The major biological process enriched in the unique hub of SARS-CoV-2 significantly differ from SARS-CoV, related to interferon signaling, regulation of viral process and influenza-A enzymatic pathway. Predicted dietary supplements can improve SARS-CoV-2 infected person''s health by boosting the host immunity/reducing inflammation. To the best of our knowledge this is the first report on co-expression network mediated biological process in human gut enterocytes to predict dietary supplements/compounds.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enterocytes / Severe acute respiratory syndrome-related coronavirus / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.104892

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enterocytes / Severe acute respiratory syndrome-related coronavirus / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.104892