Therapeutic approaches for SARS-CoV-2 infection.
Methods
; 195: 29-43, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1213580
ABSTRACT
Therapeutic approaches to COVID-19 treatment require appropriate inhibitors to target crucial proteins of SARS-CoV-2 replication machinery. It's been approximately 12 months since the pandemic started, yet no known specific drugs are available. However, research progresses with time in terms of high throughput virtual screening (HTVS) and rational design of repurposed, novel synthetic and natural products discovery by understanding the viral life cycle, immuno-pathological and clinical outcomes in patients based on host's nutritional, metabolic, and lifestyle status. Further, complementary and alternative medicine (CAM) approaches have also improved resiliency and immune responses. In this article, we summarize all the therapeutic antiviral strategies for COVID-19 drug discovery including computer aided virtual screening, repurposed drugs, immunomodulators, vaccines, plasma therapy, various adjunct therapies, and phage technology to unravel insightful mechanistic pathways of targeting SARS-CoV-2 and host's intrinsic, innate immunity at multiple checkpoints that aid in the containment of the disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Adrenal Cortex Hormones
/
Drug Discovery
/
COVID-19 Vaccines
/
COVID-19
/
COVID-19 Drug Treatment
Type of study:
Prognostic study
Topics:
Traditional medicine
/
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Methods
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
J.ymeth.2021.04.026
Similar
MEDLINE
...
LILACS
LIS