Your browser doesn't support javascript.
Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: a test-negative design.
Stowe, Julia; Tessier, Elise; Zhao, H; Guy, Rebecca; Muller-Pebody, Berit; Zambon, Maria; Andrews, Nick; Ramsay, Mary; Lopez Bernal, Jamie.
  • Stowe J; Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
  • Tessier E; Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
  • Zhao H; Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
  • Guy R; Healthcare Associated Infections and Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
  • Muller-Pebody B; Healthcare Associated Infections and Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
  • Zambon M; Virus Reference Department, National Infection Service, Public Health England, London, UK.
  • Andrews N; Statistics, Modelling and Economics Department, National Infection Service, Public Health England, London, UK.
  • Ramsay M; Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
  • Lopez Bernal J; Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
Int J Epidemiol ; 50(4): 1124-1133, 2021 08 30.
Article in English | MEDLINE | ID: covidwho-1387893
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT

BACKGROUND:

The impact of SARS-CoV-2 alongside influenza is a major concern in the northern hemisphere as winter approaches.

METHODS:

Test data for influenza and SARS-CoV-2 from national surveillance systems between 20 January 2020 and 25 April 2020 were used to estimate influenza infection on the risk of SARS-CoV-2 infection. A test-negative design was used to assess the odds of SARS-CoV-2 in those who tested positive for influenza compared with those who tested negative. The severity of SARS-CoV-2 was also assessed using univariable and multivariable analyses.

RESULTS:

The risk of testing positive for SARS-CoV-2 was 58% lower among influenza-positive cases and patients with a coinfection had a risk of death of 5.92 (95% confidence interval 3.21-10.91) times greater than among those with neither influenza nor SARS-CoV-2. The odds of ventilator use or death and intensive care unit admission or death were greatest among coinfected patients.

CONCLUSIONS:

Coinfection of these viruses could have a significant impact on morbidity, mortality and health-service demand.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / Coinfection / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Epidemiol Year: 2021 Document Type: Article Affiliation country: IJE

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / Coinfection / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Epidemiol Year: 2021 Document Type: Article Affiliation country: IJE