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Potential Use of Antigen-Based Rapid Test for SARS-CoV-2 in Respiratory Specimens in Low-Resource Settings in Egypt for Symptomatic Patients and High-Risk Contacts.
Abdelrazik, Abeer Mohamed; Elshafie, Shahira Morsy; Abdelaziz, Hossam M.
  • Abdelrazik AM; Clinical Pathology Department, Faculty of Medicine, Fayoum University Hospital, Fayoum, Egypt.
  • Elshafie SM; Clinical Pathology Department, Faculty of Medicine, Fayoum University Hospital, Fayoum, Egypt.
  • Abdelaziz HM; Clinical Pathology Department, Faculty of Medicine, Fayoum University Hospital, Fayoum, Egypt.
Lab Med ; 52(2): e46-e49, 2021 Mar 15.
Article in English | MEDLINE | ID: covidwho-1214639
ABSTRACT

OBJECTIVE:

Because of the rapidly emerging SARS-CoV-2 pandemic and its wide public health challenges, rapid diagnosis is essential to decrease the spread. Antigen-based rapid detection tests are available; however, insufficient data about their performance are available.

METHODS:

The lateral-flow immunochromatographic BIOCREDIT COVID-19 antigen test was evaluated using nasopharyngeal swabs in a viral transport medium from patients with confirmed infection, contacts, and exposed healthcare professionals at Fayoum University Hospital in Egypt. Test performance was determined in comparison to the SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (RT-PCR) test.

RESULTS:

Three hundred ten specimens from 3 categories-patients with confirmed diagnoses of COVID-19, contacts, and exposed healthcare professionals-were included; 188 specimens were RT-PCR-positive, from which 81 were detected by rapid antigen test. Overall sensitivity was 43.1%. Sensitivity was significantly higher in specimens with high viral loads.

CONCLUSION:

Poor sensitivity of the BIOCREDIT COVID-19 test does not permit its use for diagnosis, and it can only be used in conjunction with RT-PCR for screening.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoassay / COVID-19 Serological Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male Country/Region as subject: Africa Language: English Journal: Lab Med Year: 2021 Document Type: Article Affiliation country: Labmed

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoassay / COVID-19 Serological Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male Country/Region as subject: Africa Language: English Journal: Lab Med Year: 2021 Document Type: Article Affiliation country: Labmed