COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria.

Gerber, Gloria F; Yuan, Xuan; Yu, Jia; Cher, Benjamin A Y; Braunstein, Evan M; Chaturvedi, Shruti; Brodsky, Robert A

Gerber, Gloria F; Yuan, Xuan; Yu, Jia; Cher, Benjamin A Y; Braunstein, Evan M; Chaturvedi, Shruti; Brodsky, Robert A.

Gerber GF; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Yuan X; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Yu J; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Cher BAY; University of Michigan Medical School, Ann Arbor, MI.
Braunstein EM; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Chaturvedi S; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Brodsky RA; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.

Blood ; 137(26): 3670-3673, 2021 07 01.

Article in English | MEDLINE | ID: covidwho-1215089

Subject(s)

Anemia, Hemolytic/etiology; COVID-19 Vaccines/adverse effects; COVID-19; Complement Pathway, Alternative/drug effects; Hemoglobinuria, Paroxysmal/blood; Hemolysis/drug effects; SARS-CoV-2; Spike Glycoprotein, Coronavirus/adverse effects; 2019-nCoV Vaccine mRNA-1273; Adult; Anemia, Hemolytic/prevention & control; Antibodies, Monoclonal, Humanized/therapeutic use; BNT162 Vaccine; Binding, Competitive; Clone Cells; Complement Factor D/antagonists & inhibitors; Complement Factor H/metabolism; Complement Inactivating Agents/therapeutic use; Erythrocytes/drug effects; Female; Hemoglobinuria, Paroxysmal/drug therapy; Heparitin Sulfate/metabolism; Humans; Male; Middle Aged; Protein Subunits; Spike Glycoprotein, Coronavirus/metabolism; Spike Glycoprotein, Coronavirus/pharmacology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement Pathway, Alternative / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Hemoglobinuria, Paroxysmal / Hemolysis / Anemia, Hemolytic Type of study: Case report Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Blood Year: 2021 Document Type: Article

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