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Human cell receptors: potential drug targets to combat COVID-19.
Raghav, Pawan Kumar; Kalyanaraman, Keerthana; Kumar, Dinesh.
  • Raghav PK; , New Delhi, India. pwnrghv@gmail.com.
  • Kalyanaraman K; Amity Institute of Biotechnology, Amity University, Sector-125, Noida, Uttar Pradesh, India.
  • Kumar D; ICMR-National Institute of Cancer Prevention & Research, Noida, 201301, India. kdinesh777@gmail.com.
Amino Acids ; 53(6): 813-842, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1216222
Semantic information from SemMedBD (by NLM)
1. Pharmaceutical Preparations TREATS COVID-19
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
COVID-19
2. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
3. Serine Endopeptidases PART_OF integral to membrane
Subject
Serine Endopeptidases
Predicate
PART_OF
Object
integral to membrane
4. Transection (procedure) TREATS Genus: Coronavirus
Subject
Transection (procedure)
Predicate
TREATS
Object
Genus: Coronavirus
5. Body tissue LOCATION_OF angiotensin converting enzyme 2
Subject
Body tissue
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
6. Organ LOCATION_OF angiotensin converting enzyme 2
Subject
Organ
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
7. Transection (procedure) TREATS Human body
Subject
Transection (procedure)
Predicate
TREATS
Object
Human body
8. Immune Cell LOCATION_OF angiotensin converting enzyme 2
Subject
Immune Cell
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
9. Transection (procedure) TREATS COVID-19
Subject
Transection (procedure)
Predicate
TREATS
Object
COVID-19
10. Drug Delivery Systems TREATS COVID-19
Subject
Drug Delivery Systems
Predicate
TREATS
Object
COVID-19
11. Pharmaceutical Preparations TREATS COVID-19
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
COVID-19
12. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
13. Serine Endopeptidases PART_OF integral to membrane
Subject
Serine Endopeptidases
Predicate
PART_OF
Object
integral to membrane
14. Transection (procedure) TREATS Genus: Coronavirus
Subject
Transection (procedure)
Predicate
TREATS
Object
Genus: Coronavirus
15. Body tissue LOCATION_OF angiotensin converting enzyme 2
Subject
Body tissue
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
16. Organ LOCATION_OF angiotensin converting enzyme 2
Subject
Organ
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
17. Transection (procedure) TREATS Human body
Subject
Transection (procedure)
Predicate
TREATS
Object
Human body
18. Immune Cell LOCATION_OF angiotensin converting enzyme 2
Subject
Immune Cell
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
19. Transection (procedure) TREATS COVID-19
Subject
Transection (procedure)
Predicate
TREATS
Object
COVID-19
20. Drug Delivery Systems TREATS COVID-19
Subject
Drug Delivery Systems
Predicate
TREATS
Object
COVID-19
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) has announced that COVID-19 is a pandemic having a higher spread rate rather than the mortality. Identification of a potential approach or therapy against COVID-19 is still under consideration. Therefore, it is essential to have an insight into SARS-CoV-2, its interacting partner, and domains for an effective treatment. The present study is divided into three main categories, including SARS-CoV-2 prominent receptor and its expression levels, other interacting partners, and their binding domains. The first section focuses primarily on coronaviruses' general aspects (SARS-CoV-2, SARS-CoV, and the Middle East Respiratory Syndrome Coronaviruses (MERS-CoV)) their structures, similarities, and mode of infections. The second section discusses the host receptors which includes the human targets of coronaviruses like dipeptidyl peptidase 4 (DPP4), CD147, CD209L, Angiotensin-Converting Enzyme 2 (ACE2), and other miscellaneous targets (type-II transmembrane serine proteases (TTSPs), furin, trypsin, cathepsins, thermolysin, elastase, phosphatidylinositol 3-phosphate 5-kinase, two-pore segment channel, and epithelium sodium channel C-α subunit). The human cell receptor, ACE2 plays an essential role in the Renin-Angiotensin system (RAS) pathway and COVID-19. Thus, this section also discusses the ACE2 expression and risk of COVID-19 infectivity in various organs and tissues such as the liver, lungs, intestine, heart, and reproductive system in the human body. Absence of ACE2 protein expression in immune cells could be used for limiting the SARS-CoV-2 infection. The third section covers the current available approaches for COVID-19 treatment. Overall, this review focuses on the critical role of human cell receptors involved in coronavirus pathogenesis, which would likely be used in designing target-specific drugs to combat COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Receptors, Virus / Receptors, Cell Surface / COVID-19 Subject: Antiviral Agents / Receptors, Virus / Receptors, Cell Surface / COVID-19 Type of study: Prognostic study Language: English Journal: Amino Acids Clinical aspect: Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Receptors, Virus / Receptors, Cell Surface / COVID-19 Subject: Antiviral Agents / Receptors, Virus / Receptors, Cell Surface / COVID-19 Type of study: Prognostic study Language: English Journal: Amino Acids Clinical aspect: Etiology / Therapy Year: 2021
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