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Association Between Statin Use Prior to Admission and Lower Coronavirus Disease 2019 (COVID-19) Severity in Patients With Cardiovascular Disease or Risk Factors.
Ikari, Yuji; Matsue, Yuya; Torii, Sho; Hasegawa, Misaki; Aihara, Kazuki; Kuroda, Shunsuke; Sano, Takahide; Kitai, Takeshi; Yonetsu, Taishi; Kohsaka, Shun; Kishi, Takuya; Komuro, Issei; Hirata, Ken-Ichi; Node, Koichi; Matsumoto, Shingo.
  • Ikari Y; Department of Cardiology, Tokai University School of Medicine.
  • Matsue Y; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine.
  • Torii S; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine.
  • Hasegawa M; Department of Cardiology, Tokai University School of Medicine.
  • Aihara K; Department of Cardiology, Tokai University School of Medicine.
  • Kuroda S; Department of Cardiology, Tokai University School of Medicine.
  • Sano T; Department of Cardiology, Kameda Medical Center.
  • Kitai T; Department of Cardiovascular Medicine, Cleveland Clinic.
  • Yonetsu T; Department of Cardiovascular Medicine, Toho University Graduate School of Medicine.
  • Kohsaka S; Department of Cardiology, Ebara Hospital.
  • Kishi T; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital.
  • Komuro I; Department of Interventional Cardiology, Tokyo Medical and Dental University.
  • Hirata KI; Department of Cardiology, Keio University School of Medicine.
  • Node K; Department of Graduate School of Medicine (Cardiology), International University of Health and Welfare.
  • Matsumoto S; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
Circ J ; 85(6): 939-943, 2021 05 25.
Article in English | MEDLINE | ID: covidwho-1216946
Semantic information from SemMedBD (by NLM)
1. Cardiovascular Diseases PROCESS_OF Patients
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
Patients
2. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
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Patients
3. Low severity PROCESS_OF Patients
Subject
Low severity
Predicate
PROCESS_OF
Object
Patients
4. Heart Disease Risk Factors PREDISPOSES COVID-19
Subject
Heart Disease Risk Factors
Predicate
PREDISPOSES
Object
COVID-19
5. Heart Disease Risk Factors PROCESS_OF Patients
Subject
Heart Disease Risk Factors
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PROCESS_OF
Object
Patients
6. Cardiovascular Diseases PROCESS_OF Patients
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
Patients
7. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
Object
Patients
8. Low severity PROCESS_OF Patients
Subject
Low severity
Predicate
PROCESS_OF
Object
Patients
9. Heart Disease Risk Factors PREDISPOSES COVID-19
Subject
Heart Disease Risk Factors
Predicate
PREDISPOSES
Object
COVID-19
10. Heart Disease Risk Factors PROCESS_OF Patients
Subject
Heart Disease Risk Factors
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

Cardiovascular diseases and/or risk factors (CVDRF) have been reported as risk factors for severe coronavirus disease 2019 (COVID-19).Methods and 

Results:

In total, we selected 693 patients with CVDRF from the CLAVIS-COVID database of 1,518 cases in Japan. The mean age was 68 years (35% females). Statin use was reported by 31% patients at admission. Statin users exhibited lower incidence of extracorporeal membrane oxygenation (ECMO) insertion (1.4% vs. 4.6%, odds ratio [OR] 0.295, P=0.037) and septic shock (1.4% vs. 6.5%, OR 0.205, P=0.004) despite having more comorbidities such as diabetes mellitus.

CONCLUSIONS:

This study suggests the potential benefits of statins use against COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Admission / Cardiovascular Diseases / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Dyslipidemias / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Circ J Journal subject: Vascular Diseases / Cardiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Admission / Cardiovascular Diseases / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Dyslipidemias / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Circ J Journal subject: Vascular Diseases / Cardiology Year: 2021 Document Type: Article