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Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Wang, Huai; Yang, Jiankang.
  • Wang H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Dali University, Dali, China.
  • Yang J; Institute of Translational Medicine for Metabolic Diseases, Dali University, Dali, China.
Pathol Oncol Res ; 27: 612969, 2021.
Article in English | MEDLINE | ID: covidwho-1217047
ABSTRACT
The epidemic of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in the world pose a global health emergency. Cancer has been identified as a risk factor for the novel Coronavirus disease 2019 (COVID-19). The ACE2 and TMPRSS2 have been implicated in SARS-CoV-2 infection for mediating viral entry into the host cell. However, a systematic analysis of aberrant expression of ACE2 and TMPRSS2 was not yet reported in multiple human cancers. Here, we analyzed gene expression of ACE2 and TMPRSS2 across 31 types of tumors. Notably, overexpression of ACE2 and TMPRSS2 have been observed in colorectal cancer including colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). In addition, the colorectal tumors with upregulated gene expressing presented with decreased DNA methylation levels. DNA methylation might be one of the reasons for abnormal expression of ACE2 and TMPRSS2. Conclusively, colorectal cancer was the only cancer with the upregulated expression of ACE2 and TMPRSS2. More care of colorectal cancer patients is needed in multiple cancers affected by the COVID-19 outbreak.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Colorectal Neoplasms / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Pathol Oncol Res Journal subject: Neoplasms / Pathology Year: 2021 Document Type: Article Affiliation country: Pore.2021.612969

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Colorectal Neoplasms / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Pathol Oncol Res Journal subject: Neoplasms / Pathology Year: 2021 Document Type: Article Affiliation country: Pore.2021.612969