Your browser doesn't support javascript.
The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms.
Urra, José Miguel; Ferreras-Colino, Elisa; Contreras, Marinela; Cabrera, Carmen M; Fernández de Mera, Isabel G; Villar, Margarita; Cabezas-Cruz, Alejandro; Gortázar, Christian; de la Fuente, José.
  • Urra JM; Immunology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.
  • Ferreras-Colino E; Medicine School, Universidad de Castilla la Mancha (UCLM), Ciudad Real, Spain.
  • Contreras M; SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.
  • Cabrera CM; Interdisciplinary Laboratory of Clinical Analysis, Interlab-UMU, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, Spain.
  • Fernández de Mera IG; Immunology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.
  • Villar M; Medicine School, Universidad de Castilla la Mancha (UCLM), Ciudad Real, Spain.
  • Cabezas-Cruz A; SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.
  • Gortázar C; SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.
  • de la Fuente J; Biochemistry Section, Faculty of Science and Chemical Technologies, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha, Ciudad Real, Spain.
J Med Virol ; 93(4): 2065-2075, 2021 04.
Article in English | MEDLINE | ID: covidwho-1217368
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. Alpha-Gal Antibody|GAL INTERACTS_WITH Membrane Proteins
Subject
Alpha-Gal Antibody|GAL
Predicate
INTERACTS_WITH
Object
Membrane Proteins
2. Polysaccharides CAUSES Immune
Subject
Polysaccharides
Predicate
CAUSES
Object
Immune
3. opsonization PROCESS_OF Animal Model
Subject
opsonization
Predicate
PROCESS_OF
Object
Animal Model
4. galactosyl-(1-3)galactose AFFECTS COVID-19
Subject
galactosyl-(1-3)galactose
Predicate
AFFECTS
Object
COVID-19
5. Antibody Formation PROCESS_OF Patients
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Patients
6. Inflammatory Response ASSOCIATED_WITH Anti-Immunoglobulin E antibody|IGHE
Subject
Inflammatory Response
Predicate
ASSOCIATED_WITH
Object
Anti-Immunoglobulin E antibody|IGHE
7. galactosyl-(1-3)galactose AUGMENTS Immune response
Subject
galactosyl-(1-3)galactose
Predicate
AUGMENTS
Object
Immune response
8. Epitopes PART_OF Bacteria
Subject
Epitopes
Predicate
PART_OF
Object
Bacteria
9. Intervention regimes PREVENTS COVID-19
Subject
Intervention regimes
Predicate
PREVENTS
Object
COVID-19
10. Alpha-Gal Antibody|GAL INTERACTS_WITH Membrane Proteins
Subject
Alpha-Gal Antibody|GAL
Predicate
INTERACTS_WITH
Object
Membrane Proteins
11. Polysaccharides CAUSES Immune
Subject
Polysaccharides
Predicate
CAUSES
Object
Immune
12. opsonization PROCESS_OF Animal Model
Subject
opsonization
Predicate
PROCESS_OF
Object
Animal Model
13. galactosyl-(1-3)galactose AFFECTS COVID-19
Subject
galactosyl-(1-3)galactose
Predicate
AFFECTS
Object
COVID-19
14. Antibody Formation PROCESS_OF Patients
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Patients
15. Inflammatory Response ASSOCIATED_WITH Anti-Immunoglobulin E antibody|IGHE
Subject
Inflammatory Response
Predicate
ASSOCIATED_WITH
Object
Anti-Immunoglobulin E antibody|IGHE
16. galactosyl-(1-3)galactose AUGMENTS Immune response
Subject
galactosyl-(1-3)galactose
Predicate
AUGMENTS
Object
Immune response
17. Epitopes PART_OF Bacteria
Subject
Epitopes
Predicate
PART_OF
Object
Bacteria
18. Intervention regimes PREVENTS COVID-19
Subject
Intervention regimes
Predicate
PREVENTS
Object
COVID-19
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide. Characterization of the immunological mechanisms involved in disease symptomatology and protective response is important to progress in disease control and prevention. Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galß1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response against pathogenic viruses and other microorganisms containing this modification on membrane proteins mediated by anti-α-Gal immunoglobulin M (IgM)/IgG antibodies produced in response to bacterial microbiota. In addition to anti-α-Gal antibody-mediated pathogen opsonization, this glycan induces various immune mechanisms that have shown protection in animal models against infectious diseases without inflammatory responses. In this study, we hypothesized that the immune response to α-Gal may contribute to the control of COVID-19. To address this hypothesis, we characterized the antibody response to α-Gal in patients at different stages of COVID-19 and in comparison with healthy control individuals. The results showed that while the inflammatory response and the anti-SARS-CoV-2 (Spike) IgG antibody titers increased, reduction in anti-α-Gal IgE, IgM, and IgG antibody titers and alteration of anti-α-Gal antibody isotype composition correlated with COVID-19 severity. The results suggested that the inhibition of the α-Gal-induced immune response may translate into more aggressive viremia and severe disease inflammatory symptoms. These results support the proposal of developing interventions such as probiotics based on commensal bacteria with α-Gal epitopes to modify the microbiota and increase α-Gal-induced protective immune response and reduce severity of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Disaccharides / Immunity, Humoral / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26575

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Disaccharides / Immunity, Humoral / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26575