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Evaluation of serum hepatic enzyme activities in different COVID-19 phenotypes.
Liao, Fan-Lu; Peng, Ding-Hui; Chen, Wei; Hu, Han-Ning; Tang, Peng; Liu, Yan-Yuan; Luo, Yi; Yao, Tao.
  • Liao FL; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Peng DH; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Chen W; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Hu HN; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Tang P; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu YY; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Luo Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Yao T; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.
J Med Virol ; 93(4): 2365-2373, 2021 04.
Article in English | MEDLINE | ID: covidwho-1217386
Semantic information from SemMedBD (by NLM)
1. Evaluation TREATS COVID-19
Subject
Evaluation
Predicate
TREATS
Object
COVID-19
2. Liver damage COEXISTS_WITH COVID-19
Subject
Liver damage
Predicate
COEXISTS_WITH
Object
COVID-19
3. glycyrrhizic acid TREATS COVID-19
Subject
glycyrrhizic acid
Predicate
TREATS
Object
COVID-19
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. glycyrrhizic acid TREATS Patients
Subject
glycyrrhizic acid
Predicate
TREATS
Object
Patients
6. Alanine Transaminase PART_OF Liver
Subject
Alanine Transaminase
Predicate
PART_OF
Object
Liver
7. Alkaline Phosphatase TREATS Patients
Subject
Alkaline Phosphatase
Predicate
TREATS
Object
Patients
8. Gamma-glutamyl transferase TREATS Patients
Subject
Gamma-glutamyl transferase
Predicate
TREATS
Object
Patients
9. Oxidoreductase TREATS Patients
Subject
Oxidoreductase
Predicate
TREATS
Object
Patients
10. superoxide dismutase TREATS Patients
Subject
superoxide dismutase
Predicate
TREATS
Object
Patients
11. Diammonium Glycyrrhizinate TREATS Patients
Subject
Diammonium Glycyrrhizinate
Predicate
TREATS
Object
Patients
12. Atypical Lipoma PROCESS_OF Patients
Subject
Atypical Lipoma
Predicate
PROCESS_OF
Object
Patients
13. superoxide dismutase INHIBITS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
superoxide dismutase
Predicate
INHIBITS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
14. Liver Dysfunction PROCESS_OF Patients
Subject
Liver Dysfunction
Predicate
PROCESS_OF
Object
Patients
15. Serum blood tests USES Measurement of liver enzyme
Subject
Serum blood tests
Predicate
USES
Object
Measurement of liver enzyme
16. Evaluation TREATS COVID-19
Subject
Evaluation
Predicate
TREATS
Object
COVID-19
17. Liver damage COEXISTS_WITH COVID-19
Subject
Liver damage
Predicate
COEXISTS_WITH
Object
COVID-19
18. glycyrrhizic acid TREATS COVID-19
Subject
glycyrrhizic acid
Predicate
TREATS
Object
COVID-19
19. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
20. glycyrrhizic acid TREATS Patients
Subject
glycyrrhizic acid
Predicate
TREATS
Object
Patients
21. Alanine Transaminase PART_OF Liver
Subject
Alanine Transaminase
Predicate
PART_OF
Object
Liver
22. Alkaline Phosphatase TREATS Patients
Subject
Alkaline Phosphatase
Predicate
TREATS
Object
Patients
23. Gamma-glutamyl transferase TREATS Patients
Subject
Gamma-glutamyl transferase
Predicate
TREATS
Object
Patients
24. Oxidoreductase TREATS Patients
Subject
Oxidoreductase
Predicate
TREATS
Object
Patients
25. superoxide dismutase TREATS Patients
Subject
superoxide dismutase
Predicate
TREATS
Object
Patients
26. Diammonium Glycyrrhizinate TREATS Patients
Subject
Diammonium Glycyrrhizinate
Predicate
TREATS
Object
Patients
27. Atypical Lipoma PROCESS_OF Patients
Subject
Atypical Lipoma
Predicate
PROCESS_OF
Object
Patients
28. superoxide dismutase INHIBITS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
superoxide dismutase
Predicate
INHIBITS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
29. Liver Dysfunction PROCESS_OF Patients
Subject
Liver Dysfunction
Predicate
PROCESS_OF
Object
Patients
30. Serum blood tests USES Measurement of liver enzyme
Subject
Serum blood tests
Predicate
USES
Object
Measurement of liver enzyme
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease. Our understanding of the clinical characteristics of liver damage and the relationship with disease severity in COVID-19 is still limited. To investigate the serum hepatic enzyme activities in different phenotypes of COVID-19 patients, evaluate their relationship with the illness severity and analyze the correlation of glycyrrhizin treatment and abnormal liver enzyme activities, one hundred and forty-seven patients with COVID-19 were enrolled in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LDH), Y-glutamyl transferase (GGT), superoxide dismutase (SOD), and alkaline phosphatase (ALP) were analyzed in these patients. Patients with diammonium glycyrrhizinate (DG) treatment were further investigated. Of the 147 patients, 56 (38.1%) had abnormal ALT activity and 80 (54.4%) had abnormal AST activity. The peak of abnormal hepatic enzyme activities occurred at 3 to 6 days after on admission. Serum AST and LDH levels were elevated, while the SOD level was decreased in severe and critical patients, compared with mild cases. DG treatment may alleviate the abnormal liver enzyme activities in non-critical COVID-19 patients. Abnormal liver functions may be observed in patients with COVID-19, and were associated with SARS-CoV-2-induced acute liver damage. Glycyrrhizin treatment may be an effective therapeutic approach for the outcome of abnormal hepatic enzyme activities in severe COVID-19 cases. Serum hepatic enzyme tests may reflect the illness severity and should be monitored.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26729

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26729