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The peripheral and core regions of virus-host network of COVID-19.
Wang, Bingbo; Dong, Xianan; Hu, Jie; Ma, Xiujuan; Han, Chao; Wang, Yajun; Gao, Lin.
  • Wang B; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Dong X; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Hu J; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Ma X; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Han C; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Wang Y; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Gao L; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
Brief Bioinform ; 22(6)2021 11 05.
Article in English | MEDLINE | ID: covidwho-1217814
ABSTRACT
Two thousand nineteen novel coronavirus SARS-CoV-2, the pathogen of COVID-19, has caused a catastrophic pandemic, which has a profound and widespread impact on human lives and social economy globally. However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Repositioning / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal subject: Biology / Medical Informatics Year: 2021 Document Type: Article Affiliation country: Bib

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Repositioning / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal subject: Biology / Medical Informatics Year: 2021 Document Type: Article Affiliation country: Bib