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Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada.
Sjaarda, Calvin P; Guthrie, Jennifer L; Mubareka, Samira; Simpson, Jared T; Hamelin, Bettina; Wong, Henry; Mortimer, Leanne; Slinger, Robert; McArthur, Andrew G; Desjardins, Marc; McGeer, Allison; Mazzulli, Tony; Douchant, Katya; Brabant-Kirwan, Danielle; Fattouh, Ramzi; Campigotto, Aaron; Patel, Samir N; Fittipaldi, Nahuel; Colautti, Robert I; Sheth, Prameet M.
  • Sjaarda CP; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada calvin.sjaarda@queensu.ca.
  • Guthrie JL; Queen's Genomics Lab at Ongwanada (Q-GLO), Ongwanada Resource Centre, Kingston, Ontario, Canada.
  • Mubareka S; Public Health Ontario, Toronto, Ontario, Canada.
  • Simpson JT; Sunnybrook Health Science Centre, Division of Infectious Diseases, Toronto, Ontario, Canada.
  • Hamelin B; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Wong H; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Mortimer L; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
  • Slinger R; Ontario Genomics Institute, Toronto, Ontario, Canada.
  • McArthur AG; Division of Microbiology, Kingston Health Sciences Centre, Kingston, Ontario, Canada.
  • Desjardins M; Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada.
  • McGeer A; Department of Laboratory Medicine and Pathology, CHEO, Ottawa, Ontario, Canada.
  • Mazzulli T; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Douchant K; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Brabant-Kirwan D; Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
  • Fattouh R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Campigotto A; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
  • Patel SN; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.
  • Fittipaldi N; Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada.
  • Colautti RI; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Sheth PM; Department of Microbiology, Mount Sinai Hospital, University Health Network, Toronto, Ontario, Canada.
mSphere ; 6(3)2021 05 05.
Article in English | MEDLINE | ID: covidwho-1218209
ABSTRACT
Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages. The reported mutation rate (∼10-6 nucleotide [nt]-1 cycle-1) for SARS-CoV-2 is typical for coronaviruses. Analysis of published SARS-CoV-2 genomes revealed that the G614 spike protein mutation has dominated infections in Ontario and that SARS-CoV-2 lineages present in Ontario have not differed significantly in their rate of spread. These results suggest that the SARS-CoV-2 population circulating in Ontario has not changed significantly to date. However, ongoing genome monitoring is essential for identification of new variants and lineages that may contribute to increased viral transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Variation / Genome, Viral / Mutation Rate / Spike Glycoprotein, Coronavirus / SARS-CoV-2 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: North America Language: English Year: 2021 Document Type: Article Affiliation country: MSphere.00011-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Variation / Genome, Viral / Mutation Rate / Spike Glycoprotein, Coronavirus / SARS-CoV-2 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: North America Language: English Year: 2021 Document Type: Article Affiliation country: MSphere.00011-21