Your browser doesn't support javascript.
ATTR amyloidosis during the COVID-19 pandemic: insights from a global medical roundtable.
Brannagan, Thomas H; Auer-Grumbach, Michaela; Berk, John L; Briani, Chiara; Bril, Vera; Coelho, Teresa; Damy, Thibaud; Dispenzieri, Angela; Drachman, Brian M; Fine, Nowell; Gaggin, Hanna K; Gertz, Morie; Gillmore, Julian D; Gonzalez, Esther; Hanna, Mazen; Hurwitz, David R; Khella, Sami L; Maurer, Mathew S; Nativi-Nicolau, Jose; Olugemo, Kemi; Quintana, Luis F; Rosen, Andrew M; Schmidt, Hartmut H; Shehata, Jacqueline; Waddington-Cruz, Marcia; Whelan, Carol; Ruberg, Frederick L.
  • Brannagan TH; Department of Neurology, Columbia University, New York, NY, USA.
  • Auer-Grumbach M; Vienna General Hospital, Vienna, Austria.
  • Berk JL; Boston University, Boston, MA, USA.
  • Briani C; University of Padova, Padova, Italy.
  • Bril V; University Health Network, Toronto, ON, Canada.
  • Coelho T; Centro Hospitalar Universitário do Porto, Porto, Portugal.
  • Damy T; Referral Center for Cardiac Amyloidosis, Cardiology Department, APHP-Henri Mondor Hospital, Creteil, France.
  • Dispenzieri A; Mayo Clinic, Rochester, MN, USA.
  • Drachman BM; Penn Presbyterian Medical Center, Philadelphia, PA, USA.
  • Fine N; University of Calgary, Calgary, AB, Canada.
  • Gaggin HK; Massachusetts General Hospital, Boston, MA, USA.
  • Gertz M; Mayo Clinic, Rochester, MN, USA.
  • Gillmore JD; National Amyloidosis Centre, Royal Free Hospital, London, UK.
  • Gonzalez E; Hospital Puerta de Hierro of Madrid, Madrid, Spain.
  • Hanna M; Cleveland Clinic, Cleveland, OH, USA.
  • Hurwitz DR; Akcea Therapeutics, Boston, MA, USA.
  • Khella SL; University of Pennsylvania, Philadelphia, PA, USA.
  • Maurer MS; Columbia University, New York, NY, USA.
  • Nativi-Nicolau J; University of Utah, Salt Lake City, UT, USA.
  • Olugemo K; Akcea Therapeutics, Boston, MA, USA.
  • Quintana LF; Hospital Clinic, University of Barcelona, Barcelona, Spain.
  • Rosen AM; Akcea Therapeutics, Boston, MA, USA.
  • Schmidt HH; University Hospital of Münster, Münster, Germany.
  • Shehata J; Akcea Therapeutics, Boston, MA, USA.
  • Waddington-Cruz M; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Whelan C; National Amyloidosis Centre, Royal Free Hospital, London, UK.
  • Ruberg FL; Section of Cardiovascular Medicine, Department of Medicine and Amyloidosis Center, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA. Frederick.Ruberg@bmc.org.
Orphanet J Rare Dis ; 16(1): 204, 2021 05 06.
Article in English | MEDLINE | ID: covidwho-1219017
Semantic information from SemMedBD (by NLM)
1. Amyloidosis COEXISTS_WITH COVID-19
Subject
Amyloidosis
Predicate
COEXISTS_WITH
Object
COVID-19
2. Chronic disease PROCESS_OF Patients
Subject
Chronic disease
Predicate
PROCESS_OF
Object
Patients
3. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
4. Kidney LOCATION_OF COVID-19
Subject
Kidney
Predicate
LOCATION_OF
Object
COVID-19
5. Amyloidosis PROCESS_OF Patients
Subject
Amyloidosis
Predicate
PROCESS_OF
Object
Patients
6. Body tissue LOCATION_OF Amyloid Fibrils
Subject
Body tissue
Predicate
LOCATION_OF
Object
Amyloid Fibrils
7. Organ LOCATION_OF Amyloid Fibrils
Subject
Organ
Predicate
LOCATION_OF
Object
Amyloid Fibrils
8. Challenge TREATS Amyloidosis
Subject
Challenge
Predicate
TREATS
Object
Amyloidosis
9. Complication PROCESS_OF Physicians
Subject
Complication
Predicate
PROCESS_OF
Object
Physicians
10. Challenge TREATS Patients
Subject
Challenge
Predicate
TREATS
Object
Patients
11. Complication AFFECTS Amyloidosis
Subject
Complication
Predicate
AFFECTS
Object
Amyloidosis
12. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. Care setting LOCATION_OF Diagnosis
Subject
Care setting
Predicate
LOCATION_OF
Object
Diagnosis
15. Amyloidosis COEXISTS_WITH COVID-19
Subject
Amyloidosis
Predicate
COEXISTS_WITH
Object
COVID-19
16. Chronic disease PROCESS_OF Patients
Subject
Chronic disease
Predicate
PROCESS_OF
Object
Patients
17. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
18. Kidney LOCATION_OF COVID-19
Subject
Kidney
Predicate
LOCATION_OF
Object
COVID-19
19. Amyloidosis PROCESS_OF Patients
Subject
Amyloidosis
Predicate
PROCESS_OF
Object
Patients
20. Body tissue LOCATION_OF Amyloid Fibrils
Subject
Body tissue
Predicate
LOCATION_OF
Object
Amyloid Fibrils
21. Organ LOCATION_OF Amyloid Fibrils
Subject
Organ
Predicate
LOCATION_OF
Object
Amyloid Fibrils
22. Challenge TREATS Amyloidosis
Subject
Challenge
Predicate
TREATS
Object
Amyloidosis
23. Complication PROCESS_OF Physicians
Subject
Complication
Predicate
PROCESS_OF
Object
Physicians
24. Challenge TREATS Patients
Subject
Challenge
Predicate
TREATS
Object
Patients
25. Complication AFFECTS Amyloidosis
Subject
Complication
Predicate
AFFECTS
Object
Amyloidosis
26. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
27. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
28. Care setting LOCATION_OF Diagnosis
Subject
Care setting
Predicate
LOCATION_OF
Object
Diagnosis
ABSTRACT

BACKGROUND:

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing the ongoing coronavirus disease 2019 (COVID-19) pandemic has raised serious concern for patients with chronic disease. A correlation has been identified between the severity of COVID-19 and a patient's preexisting comorbidities. Although COVID-19 primarily involves the respiratory system, dysfunction in multiple organ systems is common, particularly in the cardiovascular, gastrointestinal, immune, renal, and nervous systems. Patients with amyloid transthyretin (ATTR) amyloidosis represent a population particularly vulnerable to COVID-19 morbidity due to the multisystem nature of ATTR amyloidosis. MAIN BODY ATTR amyloidosis is a clinically heterogeneous progressive disease, resulting from the accumulation of amyloid fibrils in various organs and tissues. Amyloid deposition causes multisystem clinical manifestations, including cardiomyopathy and polyneuropathy, along with gastrointestinal symptoms and renal dysfunction. Given the potential for exacerbation of organ dysfunction, physicians note possible unique challenges in the management of patients with ATTR amyloidosis who develop multiorgan complications from COVID-19. While the interplay between COVID-19 and ATTR amyloidosis is still being evaluated, physicians should consider that the heightened susceptibility of patients with ATTR amyloidosis to multiorgan complications might increase their risk for poor outcomes with COVID-19.

CONCLUSION:

Patients with ATTR amyloidosis are suspected to have a higher risk of morbidity and mortality due to age and underlying ATTR amyloidosis-related organ dysfunction. While further research is needed to characterize this risk and management implications, ATTR amyloidosis patients might require specialized management if they develop COVID-19. The risks of delaying diagnosis or interrupting treatment for patients with ATTR amyloidosis should be balanced with the risk of exposure in the health care setting. Both physicians and patients must adapt to a new construct for care during and possibly after the pandemic to ensure optimal health for patients with ATTR amyloidosis, minimizing treatment interruptions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / COVID-19 Limits: Humans Language: English Journal: Orphanet J Rare Dis Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: S13023-021-01834-0

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / COVID-19 Limits: Humans Language: English Journal: Orphanet J Rare Dis Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: S13023-021-01834-0