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Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events using optical coherence tomography angiography.
Guemes-Villahoz, Noemi; Burgos-Blasco, Barbara; Vidal-Villegas, Beatriz; Donate-López, Juan; de la Muela, María Herrera; López-Guajardo, Lorenzo; Martín-Sánchez, Francisco Javier; García-Feijoó, Julián.
  • Guemes-Villahoz N; Ophthalmology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. noemiguemes@gmail.com.
  • Burgos-Blasco B; Ophthalmology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
  • Vidal-Villegas B; Ophthalmology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
  • Donate-López J; Ophthalmology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Oftared, Madrid, Spain.
  • de la Muela MH; Obstetrics and Gynecology Department, Instituto de Salud de La Mujer, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IsISSC), Madrid, Spain.
  • López-Guajardo L; Ophthalmology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Oftared, Madrid, Spain.
  • Martín-Sánchez FJ; Department of Emergency, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
  • García-Feijoó J; Ophthalmology Department, Hospital Clínico San Carlos, Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Oftared, Madrid, Spain.
Graefes Arch Clin Exp Ophthalmol ; 259(8): 2243-2249, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1219305
ABSTRACT

PURPOSE:

Thrombotic events (TE) represent one of the major complications of SARS-CoV-2 infection. The objective is to evaluate vessel density (VD) and perfusion density (PD) by optical coherence tomography angiography (OCTA) in COVID-19 patients, and compare the findings with healthy controls. The secondary objective is to evaluate if there are differences in OCTA parameters between COVID-19 patients with and without associated TE.

METHODS:

Cross-sectional case-control study that included patients with laboratory-confirmed diagnosis of COVID-19 with and without TE related to the infection and age-matched healthy controls. Ophthalmological examination and OCTA were performed 12 weeks after diagnosis. Demographic data and medical history were collected. Macular OCTA parameters in the superficial retinal plexus were analyzed according to ETDRS sectors.

RESULTS:

Ninety patients were included, 19 (20%) COVID-19 patients with associated TE, 47 (49.5%) COVID-19 patients without TE, and 29 (30.5%) healthy controls. Fifty-three (55.7%) were male, mean age 54.4 (SD 10.2) years. COVID-19 patients presented significantly lower VD than healthy controls central (p = 0.003), inner ring (p = 0.026), outer ring (p = 0.001). PD was also significantly decreased outer ring (p = 0.003), full area (p = 0.001). No differences in OCTA parameters were found between COVID-19 patients with and without TE.

CONCLUSIONS:

OCTA represents a promising tool for the in vivo assessment of microvascular changes in COVID-19. Patients with SARS-CoV-2 infection show lower VD and PD compared to healthy controls. However, no differences were found between COVID-19 when considering TE. Prospective studies are required to further evaluate the retinal microvascular involvement of SARS-CoV-2 and its impact on the vasculature of other organs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, Optical Coherence / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Graefes Arch Clin Exp Ophthalmol Year: 2021 Document Type: Article Affiliation country: S00417-021-05186-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, Optical Coherence / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Graefes Arch Clin Exp Ophthalmol Year: 2021 Document Type: Article Affiliation country: S00417-021-05186-0