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The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis.
Klassen, Stephen A; Senefeld, Jonathon W; Johnson, Patrick W; Carter, Rickey E; Wiggins, Chad C; Shoham, Shmuel; Grossman, Brenda J; Henderson, Jeffrey P; Musser, James; Salazar, Eric; Hartman, William R; Bouvier, Nicole M; Liu, Sean T H; Pirofski, Liise-Anne; Baker, Sarah E; van Helmond, Noud; Wright, R Scott; Fairweather, DeLisa; Bruno, Katelyn A; Wang, Zhen; Paneth, Nigel S; Casadevall, Arturo; Joyner, Michael J.
  • Klassen SA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
  • Senefeld JW; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
  • Johnson PW; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.
  • Carter RE; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.
  • Wiggins CC; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
  • Shoham S; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Grossman BJ; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO.
  • Henderson JP; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO.
  • Musser J; Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; Center for Molecular and Translational Human Infectious Diseases, Houston Methodist Research Institute, Houston, TX; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
  • Salazar E; Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
  • Hartman WR; Department of Anesthesiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Bouvier NM; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Liu STH; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Pirofski LA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.
  • Baker SE; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
  • van Helmond N; Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ.
  • Wright RS; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Director, Human Research Protection Program, Mayo Clinic, Rochester, MN.
  • Fairweather D; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.
  • Bruno KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.
  • Wang Z; Evidence-Based Practice Center, Robert D. and Patricia E. Kern Center for Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Paneth NS; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing.
  • Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  • Joyner MJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Electronic address: joyner.michael@mayo.edu.
Mayo Clin Proc ; 96(5): 1262-1275, 2021 05.
Article in English | MEDLINE | ID: covidwho-1219471
ABSTRACT
To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Mayo Clin Proc Year: 2021 Document Type: Article Affiliation country: J.mayocp.2021.02.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Mayo Clin Proc Year: 2021 Document Type: Article Affiliation country: J.mayocp.2021.02.008