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A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19: The Mayo Clinic Model.
Razonable, Raymund R; Aloia, Nicole C E; Anderson, Ryan J; Anil, Gokhan; Arndt, Lori L; Arndt, Richard F; Ausman, Sara E; Bell, Sarah J; Bierle, Dennis M; Billings, Marcie L; Bishop, Rachel K; Cramer, Carl H; Culbertson, Tracy L; Dababneh, Ala S; Derr, Amber N; Epps, Kevin; Flaker, Susan M; Ganesh, Ravindra; Gilmer, Mary A; Urena, Eric Gomez; Gulden, Christopher R; Haack, Tamara L; Hanson, Sara N; Herzog, Jenna R; Heyliger, Alexander; Hokanson, Lex D; Hopkins, Laura H; Horecki, Richard J; Krishna, Bipinchandra Hirisave; Huskins, W Charles; Jackson, Tammy A; Johnson, Ryan R; Jorgenson, Betty; Kudrna, Cory; Kennedy, Brian D; Klingsporn, Mary K; Kottke, Brian; Larsen, Jennifer J; Lessard, Sarah R; Lutwick, Larry I; Malone, Edward J; Matoush, Jennifer A; Micallef, Ivana N; Moehnke, Darcie E; Mohamed, Muhanad; Ness, Colleena N; Olson, Shelly M; Orenstein, Robert; Palraj, Raj; Patel, Janki.
  • Razonable RR; Division of Infectious Diseases, Mayo Clinic, Rochester, MN. Electronic address: Razonable.raymund@mayo.edu.
  • Aloia NCE; Administrative Operations, Mayo Clinic Health System, Eau Claire, WI.
  • Anderson RJ; Department of Pharmacy, Mayo Clinic, Rochester, MN.
  • Anil G; Department of Obstetrics and Gynecology, Mayo Clinic Health System, Mankato, MN.
  • Arndt LL; Department of Infectious Diseases, Mayo Clinic Health System, Eau Claire, WI.
  • Arndt RF; Department of Pharmacy, Mayo Clinic Health System, Eau Claire, WI.
  • Ausman SE; Department of Pharmacy, Mayo Clinic Health System, Eau Claire, WI.
  • Bell SJ; Department of Nursing, Mayo Clinic, Rochester, MN.
  • Bierle DM; Division of General Internal Medicine, Mayo Clinic, Rochester, MN.
  • Billings ML; Division of Community Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
  • Bishop RK; Division of Infectious Diseases, Mayo Clinic, Rochester, MN; Department of Nursing, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Cramer CH; Division of Infectious Diseases, Mayo Clinic, Rochester, MN; Division of Pediatric Nephrology, Mayo Clinic, Rochester, MN.
  • Culbertson TL; Division of Infectious Diseases, Mayo Clinic, Rochester, MN; Department of Nursing, Mayo Clinic Health System, Mankato, MN.
  • Dababneh AS; Division of Infectious Diseases, Mayo Clinic, Rochester, MN.
  • Derr AN; Manager Operations, Mayo Clinic, Rochester, MN.
  • Epps K; Department of Pharmacy, Mayo Clinic, Jacksonville, FL.
  • Flaker SM; Department of Pharmacy, Mayo Clinic Health System, Red Wing, MN.
  • Ganesh R; Division of General Internal Medicine, Mayo Clinic, Rochester, MN.
  • Gilmer MA; Department of Pharmacy, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Urena EG; Division of Infectious Diseases, Mayo Clinic Health System, Mankato, MN.
  • Gulden CR; Department of Administration, Mayo Clinic Health System, Lake City, MN.
  • Haack TL; Desk Operations, Mayo Clinic, Rochester, MN.
  • Hanson SN; Department of Family Medicine, Mayo Clinic Health System, Mankato, MN.
  • Herzog JR; Administrative Operations, Mayo Clinic Health System, Albert Lea, MN.
  • Heyliger A; Department of Pharmacy, Mayo Clinic, Rochester, MN.
  • Hokanson LD; Nursing Informatics, Mayo Clinic, Rochester, MN.
  • Hopkins LH; Department of Nursing, Mayo Clinic Health System, Mankato, MN.
  • Horecki RJ; Division of Primary Care Internal Medicine, Mayo Clinic Health System, Eau Claire, WI.
  • Krishna BH; Department of Psychiatry, Mayo Clinic Health System, Mankato, MN.
  • Huskins WC; Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN.
  • Jackson TA; Department of Nursing, Mayo Clinic Health System, Eau Claire, WI.
  • Johnson RR; Department of Administration, Mayo Clinic Health System, Mankato, MN.
  • Jorgenson B; Department of Nursing, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Kudrna C; Information Technology, Mayo Clinic, Rochester, MN.
  • Kennedy BD; Department of Pharmacy, Mayo Clinic Health System, Lake City, MN.
  • Klingsporn MK; Nursing Education and Professional Development, Mayo Clinic, Rochester, MN.
  • Kottke B; Department of Nursing, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Larsen JJ; Department of Nursing, Mayo Clinic, Rochester, MN.
  • Lessard SR; Department of Pharmacy, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Lutwick LI; Department of Infectious Diseases, Mayo Clinic Health System, Eau Claire, WI.
  • Malone EJ; Department of Family Medicine, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, WI.
  • Matoush JA; Department of Nursing, Mayo Clinic, Rochester, MN.
  • Micallef IN; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Moehnke DE; Department of Nursing, Mayo Clinic, Rochester, MN.
  • Mohamed M; Department of Infectious Diseases, Mayo Clinic Health System, Eau Claire, WI.
  • Ness CN; Clinical Informatics, Mayo Clinic, Rochester, MN.
  • Olson SM; Department of Nursing, Mayo Clinic Health System, Owatonna, MN.
  • Orenstein R; Division of Infectious Diseases, Mayo Clinic Arizona, Phoenix, AZ.
  • Palraj R; Division of Infectious Diseases, Mayo Clinic, Rochester, MN.
  • Patel J; Department of Infectious Diseases, Mayo Clinic Health System, Eau Claire, WI.
Mayo Clin Proc ; 96(5): 1250-1261, 2021 05.
Article in English | MEDLINE | ID: covidwho-1219872
Semantic information from SemMedBD (by NLM)
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ABSTRACT
The administration of spike monoclonal antibody treatment to patients with mild to moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective spike monoclonal antibody infusion program. Rapid identification of a dedicated physical infrastructure was essential to circumvent the logistical challenges of caring for infectious patients while maintaining compliance with regulations and ensuring the safety of our personnel and other patients. Our partnerships and collaborations among multiple different specialties and disciplines enabled contributions from personnel with specific expertise in medicine, nursing, pharmacy, infection prevention and control, electronic health record (EHR) informatics, compliance, legal, medical ethics, engineering, administration, and other critical areas. Clear communication and a culture in which all roles are welcomed at the planning and operational tables are critical to the rapid development and refinement needed to adapt and thrive in providing this time-sensitive beneficial therapy. Our partnerships with leaders and providers outside our institutions, including those who care for underserved populations, have promoted equity in the access of monoclonal antibodies in our regions. Strong support from institutional leadership facilitated expedited action when needed, from a physical, personnel, and system infrastructure standpoint. Our ongoing real-time assessment and monitoring of our clinical program allowed us to improve and optimize our processes to ensure that the needs of our patients with COVID-19 in the outpatient setting are met.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Home Infusion Therapy / Critical Pathways / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Clinical Practice Guide / Prognostic study / Risk factors Limits: Humans Country/Region as subject: North America Language: English Journal: Mayo Clin Proc Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Home Infusion Therapy / Critical Pathways / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Clinical Practice Guide / Prognostic study / Risk factors Limits: Humans Country/Region as subject: North America Language: English Journal: Mayo Clin Proc Year: 2021 Document Type: Article