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The 1H, 15N, and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus.
de Araujo, Talita Stelling; Barbosa, Glauce Moreno; Sanches, Karoline; Azevedo, Jéssica M; Dos Santos Cabral, Katia Maria; Almeida, Marcius S; Almeida, Fabio C L.
  • de Araujo TS; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Barbosa GM; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil.
  • Sanches K; National Center of Nuclear Magnetic Resonance (CNRMN), Institute of Medical Biochemistry (IBqM)-Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Azevedo JM; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil.
  • Dos Santos Cabral KM; National Center of Nuclear Magnetic Resonance (CNRMN), Institute of Medical Biochemistry (IBqM)-Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Almeida MS; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil.
  • Almeida FCL; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Biomol NMR Assign ; 15(2): 341-345, 2021 10.
Article in English | MEDLINE | ID: covidwho-1220536
ABSTRACT
During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleocapsid Proteins / Nuclear Magnetic Resonance, Biomolecular / Middle East Respiratory Syndrome Coronavirus Language: English Journal: Biomol NMR Assign Journal subject: Molecular Biology / Nuclear Medicine Year: 2021 Document Type: Article Affiliation country: S12104-021-10027-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleocapsid Proteins / Nuclear Magnetic Resonance, Biomolecular / Middle East Respiratory Syndrome Coronavirus Language: English Journal: Biomol NMR Assign Journal subject: Molecular Biology / Nuclear Medicine Year: 2021 Document Type: Article Affiliation country: S12104-021-10027-6