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Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2.
Hassan, Sk Sarif; Attrish, Diksha; Ghosh, Shinjini; Choudhury, Pabitra Pal; Roy, Bidyut.
  • Hassan SS; Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, India. Electronic address: sarimif@gmail.com.
  • Attrish D; Dr. B. R. Ambedkar Centre For Biomedical Research (ACBR), University of Delhi (North Campus), Delhi 110007, India. Electronic address: dikshaattrish@gmail.com.
  • Ghosh S; Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata 700009, West Bengal, India. Electronic address: shinjinighosh2014@gmail.com.
  • Choudhury PP; Applied Statistics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address: pabitrapalchoudhury@gmail.com.
  • Roy B; Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address: broy@isical.ac.in.
Virus Res ; 300: 198441, 2021 07 15.
Article in English | MEDLINE | ID: covidwho-1221063
Preprint
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ABSTRACT
One of the most important proteins for COVID-19 pathogenesis in SARS-CoV-2 is the ORF3a which is the largest accessory protein among others coded by the SARS-CoV-2 genome. The major roles of the protein include virulence, infectivity, ion channel activity, morphogenesis, and virus release. The coronavirus, SARS-CoV-2 is mutating rapidly, therefore, critical study of mutations in ORF3a is certainly important from the pathogenic perspective. Here, a sum of 175 non-synonymous mutations in the ORF3a of SARS-CoV-2 were identified from 7194 complete genomes of SARS-CoV-2 available from NCBI database. Effects of these mutations on structural stability, and functions of ORF3a were also studied. Broadly, three different classes of mutations, such as neutral, disease, and mixed (neutral and disease) types of mutations were observed. Consecutive phenomena of mutations in ORF3a protein were studied based on the timeline of detection of the mutations. Considering the amino acid compositions of the ORF3a protein, twenty clusters were detected using the K-means clustering method. The present findings on 175 novel mutations of ORF3a proteins will extend our knowledge on ORF3a, a vital accessory protein in SARS-CoV-2, to enlighten the pathogenicity of this life-threatening virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virulence Factors / Viroporin Proteins / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Virus Res Journal subject: Virology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virulence Factors / Viroporin Proteins / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Virus Res Journal subject: Virology Year: 2021 Document Type: Article