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Severity and 1-month outcome of SARS-CoV-2 infection in patients with solid cancers: a Danish nationwide cohort study.
Ehmsen, S; Jakobsen, L H; Lendorf, M E; Eefsen, R L; Bentsen, L; Knoop, A S; Aggerholm-Pedersen, N; Skuladottir, H; Herrstedt, J; Jensen, L H; Rotbøl, C; Damm, M B; Wedervang, K; Glenthøj, A; Ryg, J; Frederiksen, H; Kodahl, A R.
  • Ehmsen S; Department of Oncology, Odense University Hospital, Denmark.
  • Jakobsen LH; Department of Clinical Research, University of Southern Denmark, Denmark.
  • Lendorf ME; Department of Haematology, Aalborg University Hospital, Denmark.
  • Eefsen RL; Department of Clinical Medicine, Denmark Aalborg University.
  • Bentsen L; Department of Oncology and Palliative Care, North Zealand Hospital, Denmark.
  • Knoop AS; Department of Oncology, Herlev and Gentofte hospital, Denmark.
  • Aggerholm-Pedersen N; Department of Oncology, Rigshospitalet, Denmark.
  • Skuladottir H; Department of Oncology, Rigshospitalet, Denmark.
  • Herrstedt J; Department of Oncology, Aarhus University Hospital, Denmark.
  • Jensen LH; Department of Oncology, Regional Hospital West Jutland, Denmark.
  • Rotbøl C; Department of Clinical Oncology, Zealand University Hospital Roskilde, Denmark.
  • Damm MB; Department of Oncology, University Hospital of Southern Denmark, Vejle Hospital, Denmark.
  • Wedervang K; Department of Oncology, Aalborg University, Denmark Hospital.
  • Glenthøj A; Department of Clinical Oncology, Naestved Hospital, Denmark.
  • Ryg J; Department of Oncology, Southern Jutland Hospital, Sønderborg, Denmark.
  • Frederiksen H; Department of Haematology, Rigshospitalet, Denmark.
  • Kodahl AR; Department of Clinical Research, University of Southern Denmark, Denmark.
Acta Oncol ; 60(7): 859-865, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1221269
ABSTRACT

BACKGROUND:

Cancer patients are vulnerable to infections, are older and often have comorbidities in comparison to the general population, which increases the risk for severe outcomes related to COVID-19 diagnosis.

METHODS:

This study is a prospective, nationwide study in patients with solid cancer and SARS-CoV-2 infection included between 10 March to 15 June 2020. Patient's baseline characteristics were collected. The study's primary outcome was overall survival within 30 days of verified SARS-CoV-2 infection. Secondary outcomes were hospital admission, admission to an ICU, and need for supplemental oxygen.

RESULTS:

A total of 112 patients with a cancer diagnosis and verified SARS-CoV-2 infection were identified. After one month of follow up, hospitalization was required for 54% (n = 61) and 21% of the patients had died and 14 of the 23 deceased cancer patients were ≥70 years. Most patients were classified with mild COVID-19 symptoms (66%, n = 74); however, 48% (n = 23) of the ≥70-year-olds patients were classified with severe or critical COVID-19 symptoms. Among the total study population, 61% (n = 68) had comorbidities and comorbidity were more frequently observed among the deceased (91%, n = 21) and older cancer patients (≥70 years, 81%, n = 39).

CONCLUSIONS:

Acknowledging the low sample size in this study, our work shows that age and comorbidities, but not recent cytotoxic therapy, are associated with adverse outcomes of SARS-CoV-2 infection for patients with solid cancer. Particularly, patients with progressive disease seem to be at greater risk of a fatal outcome from COVID-19.HighlightsAge, performance status, and comorbidities are strong predictors of adverse outcome in cancer patients with SARS-CoV-2 infection.Patients with progressive cancer disease seem to be at greater risk of a fatal outcome from COVID-19.Recent cytotoxic therapy, however, did not seem to be associated with increased risk for adverse outcomes of SARS-CoV-2 infection for patients with solid cancer.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: Acta Oncol Journal subject: Neoplasms Year: 2021 Document Type: Article Affiliation country: 0284186X.2021.1889659

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: Acta Oncol Journal subject: Neoplasms Year: 2021 Document Type: Article Affiliation country: 0284186X.2021.1889659