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First-Phase Ejection Fraction, a Measure of Preclinical Heart Failure, Is Strongly Associated With Increased Mortality in Patients With COVID-19.
Gu, Haotian; Cirillo, Chiara; Nabeebaccus, Adam A; Sun, Zhenxing; Fang, Lingyun; Xie, Yuji; Demir, Ozan; Desai, Nishita; He, Lin; Lü, Qing; Nakou, Eleni; O'Gallagher, Kevin; Tountas, Christos; Marvaki, Apostolia; Monaghan, Mark; Perera, Divaka; Pericao, Ana; Ryan, Matthew; Sinclair, Hannah; Stylianidis, Vasileios; Victor, Kelly; Wang, Bin; Wang, Jing; Wang, Rui; Wu, Chun; Yang, Yali; Yuan, Hongliang; Zhang, Danqing; Zhang, Yongxing; Faconti, Luca; Papachristidis, Alexandros; Zhang, Li; Carr-White, Gerald; Shah, Ajay M; Xie, Mingxing; Chowienczyk, Phil.
  • Gu H; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Cirillo C; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Nabeebaccus AA; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Sun Z; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Fang L; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Xie Y; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Demir O; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Desai N; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • He L; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Lü Q; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Nakou E; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • O'Gallagher K; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Tountas C; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Marvaki A; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Monaghan M; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Perera D; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Pericao A; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Ryan M; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Sinclair H; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Stylianidis V; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Victor K; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Wang B; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Wang J; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Wang R; King's College London Hospital, London, United Kingdom (A.A.N., E.N., K.O., C.T., A.M., M.M., A. Papachristidis, A.M.S.).
  • Wu C; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Yang Y; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Yuan H; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Zhang D; British Heart Foundation Centre, King's College London, United Kingdom (H.G., A.A.N., O.D., K.O., M.M., D.P., M.R., L. Faconti, A. Papachristidis, G.C.-W., A.M.S., P.C.).
  • Zhang Y; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Faconti L; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Papachristidis A; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Zhang L; Guy's and St Thomas' Hospital, London, United Kingdom (C.C., O.D., N.D., D.P., A. Pericao, M.R., H.S., V.S., K.V., L. Faconti, G.C.-W.).
  • Carr-White G; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Shah AM; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Xie M; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W., Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
  • Chowienczyk P; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (Z.S., L. Fang, Y.X., L.H., Q.L., B.W., J.W., R.W., C.W.,Y.Y., H.Y., D.Z., Y.Z., L.Z., M.X.).
Hypertension ; 77(6): 2014-2022, 2021 06.
Article in English | MEDLINE | ID: covidwho-1221676
ABSTRACT
Presence of heart failure is associated with a poor prognosis in patients with coronavirus disease 2019 (COVID-19). The aim of the present study was to examine whether first-phase ejection fraction (EF1), the ejection fraction measured in early systole up to the time of peak aortic velocity, a sensitive measure of preclinical heart failure, is associated with survival in patients hospitalized with COVID-19. A retrospective outcome study was performed in patients hospitalized with COVID-19 who underwent echocardiography (n=380) at the West Branch of the Union Hospital, Wuhan, China and in patients admitted to King's Health Partners in South London, United Kingdom. Association of EF1 with survival was performed using Cox proportional hazards regression. EF1 was compared in patients with COVID-19 and in historical controls with similar comorbidities (n=266) who had undergone echocardiography before the COVID-19 pandemic. In patients with COVID-19, EF1 was a strong predictor of survival in each patient group (Wuhan and London). In the combined group, EF1 was a stronger predictor of survival than other clinical, laboratory, and echocardiographic characteristics including age, comorbidities, and biochemical markers. A cutoff value of 25% for EF1 gave a hazard ratio of 5.23 ([95% CI, 2.85-9.60]; P<0.001) unadjusted and 4.83 ([95% CI, 2.35-9.95], P<0.001) when adjusted for demographics, comorbidities, hs-cTnI (high-sensitive cardiac troponin), and CRP (C-reactive protein). EF1 was similar in patients with and without COVID-19 (23.2±7.3 versus 22.0±7.6%, P=0.092, adjusted for prevalence of risk factors and comorbidities). Impaired EF1 is strongly associated with mortality in COVID-19 and probably reflects preexisting, preclinical heart failure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke Volume / Echocardiography / COVID-19 / Heart Failure Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia / Europa Language: English Journal: Hypertension Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke Volume / Echocardiography / COVID-19 / Heart Failure Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia / Europa Language: English Journal: Hypertension Year: 2021 Document Type: Article