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Current Overviews on COVID-19 Management Strategies.
Rai, Pankaj Kumar; Mueed, Zeba; Chowdhury, Abhiroop; Deval, Ravi; Kumar, Dinesh; Kamal, Mohammad A; Negi, Yogeshwar Singh; Pareek, Shubhra; Sharma, Hemlata; Poddar, Nitesh Kumar.
  • Rai PK; Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India.
  • Mueed Z; Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India.
  • Chowdhury A; School of Environment & Sustainability, O.P. Jindal Global University, Sonipat, Haryana, India.
  • Deval R; Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India.
  • Kumar D; Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India.
  • Kamal MA; West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
  • Negi YS; Department of Biosciences, Manipal University Jaipur, DehmiKalan, Jaipur-Ajmer Expressway, Jaipur, 303007, Rajasthan, India.
  • Pareek S; Department of Chemistry, Manipal University Jaipur, DehmiKalan, Jaipur-Ajmer Expressway, Jaipur-303007, Rajasthan,India.
  • Sharma H; Department of Biosciences, Manipal University Jaipur, DehmiKalan, Jaipur-Ajmer Expressway, Jaipur, 303007, Rajasthan, India.
  • Poddar NK; Department of Biosciences, Manipal University Jaipur, DehmiKalan, Jaipur-Ajmer Expressway, Jaipur, 303007, Rajasthan, India.
Curr Pharm Biotechnol ; 23(3): 361-387, 2022.
Article in English | MEDLINE | ID: covidwho-1221870
ABSTRACT
The coronavirus pandemic hit the world lately and caused acute respiratory syndrome in humans. The causative agent of the disease was soon identified by scientists as SARS-CoV-2 and later called a novel coronavirus by the general public. Due to the severity and rapid spread of the disease, WHO classifies the COVID-19 pandemic as the 6th public health emergency even after taking efforts like worldwide quarantine and restrictions. Since only symptomatic treatment is available, the best way to control the spread of the virus is by taking preventive measures. Various types of antigen/antibody detection kits and diagnostic methods are available for the diagnosis of COVID-19 patients. In recent years, various phytochemicals and repurposing drugs showing a broad range of anti-viral activities with different modes of actions have been identified. Repurposing drugs such as arbidol, hydroxychloroquine, chloroquine, lopinavir, favipiravir, remdesivir, hexamethylene amiloride, dexamethasone, tocilizumab, interferon-ß, and neutralizing antibodies exhibit in vitro anti-coronaviral properties by inhibiting multiple processes in the virus life cycle. Various research groups are involved in drug trials and vaccine development. Plant-based antiviral compounds such as baicalin, calanolides, curcumin, oxymatrine, matrine, and resveratrol exhibit different modes of action against a wide range of positive/negative sense-RNA/DNA virus, and future researches need to be conducted to ascertain their role and use in managing SARS-CoV-2. Thus this article is an attempt to review the current understanding of COVID- 19 acute respiratory disease and summarize its clinical features with their prospective control and various aspects of the therapeutic approach.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Curr Pharm Biotechnol Journal subject: Biotechnology / Pharmacology Year: 2022 Document Type: Article Affiliation country: 1389201022666210509022313

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Curr Pharm Biotechnol Journal subject: Biotechnology / Pharmacology Year: 2022 Document Type: Article Affiliation country: 1389201022666210509022313