Your browser doesn't support javascript.
COVID-19 Rehabilitation With Herbal Medicine and Cardiorespiratory Exercise: Protocol for a Clinical Study.
Gao, Yang; Zhong, Linda L D; Quach, Binh; Davies, Bruce; Ash, Garrett I; Lin, Zhi-Xiu; Feng, Yibin; Lau, Benson W M; Wagner, Peter D; Yang, Xian; Guo, Yike; Jia, Wei; Bian, Zhaoxiang; Baker, Julien S.
  • Gao Y; Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Zhong LLD; School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Quach B; Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Davies B; Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Ash GI; Neurovascular Research Laboratory, University of South Wales, Pontypridd, United Kingdom.
  • Lin ZX; Veterans Affairs Connecticut Healthcare System, West Haven, CT, United States.
  • Feng Y; Center for Medical Informatics, Yale University, New Haven, CT, United States.
  • Lau BWM; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong.
  • Wagner PD; School of Chinese Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
  • Yang X; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
  • Guo Y; Department of Medicine, University of California San Diego, La Jolla, CA, United States.
  • Jia W; Department of Computer Science, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Bian Z; Department of Computer Science, Hong Kong Baptist University, Kowloon, Hong Kong.
  • Baker JS; School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong.
JMIR Res Protoc ; 10(5): e25556, 2021 May 26.
Article in English | MEDLINE | ID: covidwho-1221875
ABSTRACT

BACKGROUND:

Recent studies have revealed that many discharged patients with COVID-19 experience ongoing symptoms months later. Rehabilitation interventions can help address the consequences of COVID-19, including medical, physical, cognitive, and psychological problems. To our knowledge, no studies have investigated the effects of rehabilitation following discharge from hospital for patients with COVID-19.

OBJECTIVE:

The specific aims of this project are to investigate the effects of a 12-week exercise program on pulmonary fibrosis in patients recovering from COVID-19. A further aim will be to examine how Chinese herbal medicines as well as the gut microbiome and its metabolites regulate immune function and possibly autoimmune deficiency in the rehabilitation process.

METHODS:

In this triple-blinded, randomized, parallel-group, controlled clinical trial, we will recruit adult patients with COVID-19 who have been discharged from hospital in Hong Kong and are experiencing impaired lung function and pulmonary function. A total of 172 eligible patients will be randomized into four equal groups (1) cardiorespiratory exercise plus Chinese herbal medicines group, (2) cardiorespiratory exercise only group, (3) Chinese herbal medicines only group, and (4) waiting list group (in which participants will receive Chinese herbal medicines after 24 weeks). These treatments will be administered for 12 weeks, with a 12-week follow-up period. Primary outcomes include dyspnea, fatigue, lung function, pulmonary function, blood oxygen levels, immune function, blood coagulation, and related blood biochemistry. Measurements will be recorded prior to initiating the above treatments and repeated at the 13th and 25th weeks of the study. The primary analysis is aimed at comparing the outcomes between groups throughout the study period with an α level of .05 (two-tailed).

RESULTS:

The trial has been approved by the university ethics committee following the Declaration of Helsinki (approval number REC/19-20/0504) in 2020. The trial has been recruiting patients. The data collection will be completed in 24 months, from January 1, 2021, to December 31, 2022.

CONCLUSIONS:

Given that COVID-19 and its sequelae would persist in human populations, important findings from this study would provide valuable insights into the mechanisms and processes of COVID-19 rehabilitation. TRIAL REGISTRATION ClinicalTrials.gov NCT04572360; https//clinicaltrials.gov/ct2/show/NCT04572360. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) PRR1-10.2196/25556.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid / Traditional medicine Language: English Journal: JMIR Res Protoc Year: 2021 Document Type: Article Affiliation country: 25556

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid / Traditional medicine Language: English Journal: JMIR Res Protoc Year: 2021 Document Type: Article Affiliation country: 25556