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Ventilatory Support in Patients with COVID-19.
Leone, Paolo Maria; Siciliano, Matteo; Simonetti, Jacopo; Lopez, Angelena; Zaman, Tanzira; Varone, Francesco; Richeldi, Luca.
  • Leone PM; Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy. paolomaria.leone@policlinicogemelli.it.
  • Siciliano M; Università Cattolica del Sacro Cuore, Rome, Italy. paolomaria.leone@policlinicogemelli.it.
  • Simonetti J; Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
  • Lopez A; Università Cattolica del Sacro Cuore, Rome, Italy.
  • Zaman T; Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
  • Varone F; Università Cattolica del Sacro Cuore, Rome, Italy.
  • Richeldi L; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Adv Exp Med Biol ; 1318: 469-483, 2021.
Article in English | MEDLINE | ID: covidwho-1222730
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the novel coronavirus disease 2019 (COVID-19) pandemic, which spread throughout the world. Acute hypoxemic respiratory failure is the most dangerous complication of COVID-19 pneumonia. To date, no specific therapeutic drugs or vaccines have been proven efficacious. Ventilatory support is still a significant challenge for physicians facing COVID-19. The mechanisms underlying hypoxemia in those patients are not fully understood, but a new physiopathology model has been proposed. Oxygen therapy should be delivered to patients with mild to moderate hypoxemia. More severe patients could benefit from other treatments (high-flow nasal cannula, noninvasive ventilation or intubation, and invasive ventilation). Given the rapid evolution of COVID-19, there has been a paucity of the high-quality data that typically inform clinical practice guidelines from professional societies, and a worldwide consensus is still lacking. This chapter aims to illustrate the potentials of ventilatory support as therapeutic options for adult and pediatric patients affected by COVID-19 pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Noninvasive Ventilation / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Child / Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-63761-3_27

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Noninvasive Ventilation / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Child / Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-63761-3_27