Dietary Supplements for COVID-19.
Adv Exp Med Biol
; 1318: 499-515, 2021.
Article
in English
| MEDLINE | ID: covidwho-1222732
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease that can rapidly escalate to respiratory failure and death. It has infected millions of people worldwide. The trajectory of this disease continues to progress in some areas of the United States and worldwide. The Institute for Health Metrics now predicts a resurgence of infections in the fall of 2020. The pathogenesis of COVID-19 includes an inflammatory phase with either resolution or the potential to accelerate to a cytokine storm, characterized by high interleukin (IL)-6 and other inflammatory markers. COVID-19 is a condition without a gold-standard treatment. The US Federal Drug Administration (FDA) issued an emergency use authorization for remdesivir in severe cases of COVID-19, which shortened the recovery time in hospitalized patients with lower respiratory tract infection in one study. Although several vaccine trials are underway, no vaccines are available for primary prevention of COVID-19 at this time. Dietary supplement sales have dramatically risen during the COVID-19 pandemic despite depressed economic conditions. Commonly used immune-modulating dietary supplements, including vitamin D, ascorbic acid, zinc, and melatonin, are reviewed in this manuscript highlighting biological plausibility for salutary benefit against COVID-19. Ongoing clinical trials recruiting subjects at the time of this writing are provided for each dietary supplement.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dietary Supplements
/
Pandemics
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Traditional medicine
/
Vaccines
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Adv Exp Med Biol
Year:
2021
Document Type:
Article
Affiliation country:
978-3-030-63761-3_29
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