Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.
J Neurol
; 268(12): 4436-4442, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1222771
ABSTRACT
BACKGROUND AND AIMS:
Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU).METHODS:
We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels.RESULTS:
We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan-Meier curves indicated that total tau levels at admission accurately predict mortality.CONCLUSIONS:
Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Intermediate Filaments
/
Neurofilament Proteins
/
Tau Proteins
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Neurol
Year:
2021
Document Type:
Article
Affiliation country:
S00415-021-10595-6
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