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Gene selection using hybrid dragonfly black hole algorithm: A case study on RNA-seq COVID-19 data.
Pashaei, Elnaz; Pashaei, Elham.
  • Pashaei E; Department of Software Engineering, Istanbul Aydin University, Istanbul, Turkey. Electronic address: elnazpashaei@aydin.edu.tr.
  • Pashaei E; Department of Computer Engineering, Istanbul Gelisim University, Istanbul, Turkey. Electronic address: epashaei@gelisim.edu.tr.
Anal Biochem ; 627: 114242, 2021 Aug 15.
Article in English | MEDLINE | ID: covidwho-1222826
ABSTRACT
This paper introduces a new hybrid approach (DBH) for solving gene selection problem that incorporates the strengths of two existing metaheuristics binary dragonfly algorithm (BDF) and binary black hole algorithm (BBHA). This hybridization aims to identify a limited and stable set of discriminative genes without sacrificing classification accuracy, whereas most current methods have encountered challenges in extracting disease-related information from a vast amount of redundant genes. The proposed approach first applies the minimum redundancy maximum relevancy (MRMR) filter method to reduce the dimensionality of feature space and then utilizes the suggested hybrid DBH algorithm to determine a smaller set of significant genes. The proposed approach was evaluated on eight benchmark gene expression datasets, and then, was compared against the latest state-of-art techniques to demonstrate algorithm efficiency. The comparative study shows that the proposed approach achieves a significant improvement as compared with existing methods in terms of classification accuracy and the number of selected genes. Moreover, the performance of the suggested method was examined on real RNA-Seq coronavirus-related gene expression data of asthmatic patients for selecting the most significant genes in order to improve the discriminative accuracy of angiotensin-converting enzyme 2 (ACE2). ACE2, as a coronavirus receptor, is a biomarker that helps to classify infected patients from uninfected in order to identify subgroups at risk for COVID-19. The result denotes that the suggested MRMR-DBH approach represents a very promising framework for finding a new combination of most discriminative genes with high classification accuracy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Algorithms / Sequence Analysis, RNA / Support Vector Machine / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Anal Biochem Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Algorithms / Sequence Analysis, RNA / Support Vector Machine / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Anal Biochem Year: 2021 Document Type: Article