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Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study.
Engels Calvo, Virginia; Cruz Melguizo, Sara; Abascal-Saiz, Alejandra; Forcén Acebal, Laura; Sánchez-Migallón, Amalia; Pintado Recarte, Pilar; Cuenca Marín, Celia; Marcos Puig, Beatriz; Del Barrio Fernández, Pablo G; Nieto Velasco, Olga; de la Cruz Conty, María Luisa; Martínez-Perez, Oscar.
  • Engels Calvo V; Fertility Unit, Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain.
  • Cruz Melguizo S; Maternal-Fetal Medicine Unit, Department Obstetrics and Gynecology, Hospital Universitario Puerta de Hierro.Majadahonda, Madrid, Spain.
  • Abascal-Saiz A; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, Spain.
  • Forcén Acebal L; Department of Gynecology and Obstetrics, University Hospital 12 de Octubre, Madrid, Spain.
  • Sánchez-Migallón A; Maternal-fetal Medicine Unit, Department of Gynecology and Obstetrics, QuirónSalud Dexeus University Hospital, Barcelona, Spain.
  • Pintado Recarte P; Department of Gynecology and Obstetrics, Gregorio Marañon University Hospital, Madrid, Spain.
  • Cuenca Marín C; Maternal-fetal Medicine Unit, Department of Gynecology and Obstetrics, Regional Hospital of Málaga, Málaga, Spain.
  • Marcos Puig B; Maternal-fetal Medicine Unit, Department of Gynecology and Obstetrics, La Fe University and Polytechnic Hospital, Valencia, Spain.
  • Del Barrio Fernández PG; Maternal-fetal Medicine Unit, Department of Gynecology and Obstetrics, University Hospital of Getafe, Madrid, Spain.
  • Nieto Velasco O; Maternal-fetal Medicine Unit, Department of Gynecology and Obstetrics, QuirónSalud Madrid University Hospital, Madrid, Spain.
  • de la Cruz Conty ML; Fundación de Investigación Biomedica, Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain.
  • Martínez-Perez O; Maternal-Fetal Medicine Unit, Department Obstetrics and Gynecology, Hospital Universitario Puerta de Hierro.Majadahonda, Madrid, Spain. Electronic address: oscarmartinezgine@gmail.com.
Fertil Steril ; 116(3): 731-740, 2021 09.
Article in English | MEDLINE | ID: covidwho-1222903
ABSTRACT

OBJECTIVE:

To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes).

DESIGN:

Multicenter, prospective, observational study.

SETTING:

78 centers participating in the Spanish COVID19 Registry. PATIENT(S) 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. INTERVENTION(S) The patients' information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. MAIN OUTCOME MEASURE(S) Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. RESULT(S) The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45-10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25-25.87), not to the type of conception. CONCLUSION(S) A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. CLINICAL TRIAL REGISTRATION NUMBER NCT04558996.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Outcome / Reproductive Techniques, Assisted / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Female / Humans / Infant / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: Fertil Steril Year: 2021 Document Type: Article Affiliation country: J.fertnstert.2021.04.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Outcome / Reproductive Techniques, Assisted / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Female / Humans / Infant / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: Fertil Steril Year: 2021 Document Type: Article Affiliation country: J.fertnstert.2021.04.005