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An Eye on COVID-19: A Meta-analysis of Positive Conjunctival Reverse Transcriptase-Polymerase Chain Reaction and SARS-CoV-2 Conjunctivitis Prevalence.
Sopp, Nicole M; Sharda, Vandhana.
  • Sharda V; Atrius Health, Newton, Massachusetts.
Optom Vis Sci ; 98(5): 429-436, 2021 05 01.
Article in English | MEDLINE | ID: covidwho-1223410
ABSTRACT

SIGNIFICANCE:

This analysis and review demonstrate that, although emerging data indicate that the prevalence of severe acute respiratory coronavirus 2 (SARS-CoV-2) on the ocular surface and coronavirus disease 2019 (COVID-19) conjunctivitis is rare, the ocular surface remains of interest as a potential inoculation and transmission site for SARS-CoV-2. Continued safety precautions should be taken as more data become available.COVID-19, caused by SARS-CoV-2, is a novel, global pandemic that has infected millions and, up to this point, caused more than two million fatalities worldwide. The ocular surface has become of interest as a possible vector for transmission by acting as a direct inoculation site, being a conduit for the virus into the respiratory system or as a method of transmission from potentially infected conjunctiva or tears. The components necessary for SARS-CoV-2 to theoretically infect ocular tissues are present binding receptors (angiotensin-converting enzyme 2 and cluster of differentiation 147) and mechanisms for cell entry (transmembrane protease serine 2 and cathepsin L). This meta-analysis of COVID-19 prevalence data indicates that SARS-CoV-2 RNA has been infrequently found in conjunctival samples when tested with reverse transcriptase-polymerase chain reaction. This review estimates the prevalence of SARS-CoV-2 on the ocular surface and prevalence of conjunctivitis in patients with laboratory-confirmed COVID-19. There is much to be learned regarding ocular tropism of SARS-CoV-2.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Conjunctivitis / Reverse Transcriptase Polymerase Chain Reaction / COVID-19 Type of study: Observational study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Optom Vis Sci Journal subject: Optometry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Conjunctivitis / Reverse Transcriptase Polymerase Chain Reaction / COVID-19 Type of study: Observational study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Optom Vis Sci Journal subject: Optometry Year: 2021 Document Type: Article