Metabolite reanalysis revealed potential biomarkers for COVID-19: a potential link with immune response.
Future Microbiol
; 16: 577-588, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1223836
ABSTRACT
Aim:
To understand the pathological progress of COVID-19 and to explore the potential biomarkers.Background:
The COVID-19 pandemic is ongoing. There is metabolomics research about COVID-19 indicating the rich information of metabolomics is worthy of further data mining.Methods:
We applied bioinformatics technology to reanalyze the published metabolomics data of COVID-19.Results:
Benzoate, ß-alanine and 4-chlorobenzoic acid were first reported to be used as potential biomarkers to distinguish COVID-19 patients from healthy individuals; taurochenodeoxycholic acid 3-sulfate, glucuronate and N,N,N-trimethyl-alanylproline betaine TMAP are the top classifiers in the receiver operating characteristic curve of COVID-severe and COVID-nonsevere patients.Conclusion:
These unique metabolites suggest an underlying immunoregulatory treatment strategy for COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Metabolome
/
Metabolomics
/
COVID-19
Type of study:
Diagnostic study
/
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Future Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
Fmb-2021-0047
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