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The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection.
D'Amore, Antonella; Gradogna, Antonella; Palombi, Fioretta; Minicozzi, Velia; Ceccarelli, Matteo; Carpaneto, Armando; Filippini, Antonio.
  • D'Amore A; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 16 Via A. Scarpa, 00161 Rome, Italy.
  • Gradogna A; Institute of Biophysics, National Research Council, Via De Marini 6, 16149 Genova, Italy.
  • Palombi F; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 16 Via A. Scarpa, 00161 Rome, Italy.
  • Minicozzi V; INFN and Department of Physics, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Roma, Italy.
  • Ceccarelli M; Department of Physics, University of Cagliari, 09042 Monserrato, Italy.
  • Carpaneto A; IOM-CNR Unità di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  • Filippini A; Institute of Biophysics, National Research Council, Via De Marini 6, 16149 Genova, Italy.
Cells ; 10(5)2021 05 07.
Article in English | MEDLINE | ID: covidwho-1223961
Semantic information from SemMedBD (by NLM)
1. naringenin TREATS COVID-19
Subject
naringenin
Predicate
TREATS
Object
COVID-19
2. Protoplasm PART_OF Homo sapiens
Subject
Protoplasm
Predicate
PART_OF
Object
Homo sapiens
3. Present COEXISTS_WITH Disease
Subject
Present
Predicate
COEXISTS_WITH
Object
Disease
4. naringenin DISRUPTS pore activity
Subject
naringenin
Predicate
DISRUPTS
Object
pore activity
5. COVID-19 MANIFESTATION_OF Coronavirus Infections
Subject
COVID-19
Predicate
MANIFESTATION_OF
Object
Coronavirus Infections
6. naringenin TREATS COVID-19
Subject
naringenin
Predicate
TREATS
Object
COVID-19
7. Protoplasm PART_OF Homo sapiens
Subject
Protoplasm
Predicate
PART_OF
Object
Homo sapiens
8. Present COEXISTS_WITH Disease
Subject
Present
Predicate
COEXISTS_WITH
Object
Disease
9. naringenin DISRUPTS pore activity
Subject
naringenin
Predicate
DISRUPTS
Object
pore activity
10. COVID-19 MANIFESTATION_OF Coronavirus Infections
Subject
COVID-19
Predicate
MANIFESTATION_OF
Object
Coronavirus Infections
ABSTRACT
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcium Channel Blockers / Calcium Channels / Flavanones / COVID-19 / Neoplasms Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10051130

Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcium Channel Blockers / Calcium Channels / Flavanones / COVID-19 / Neoplasms Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10051130