Your browser doesn't support javascript.
Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank.
Fan, Xiude; Liu, Zhengwen; Poulsen, Kyle L; Wu, Xiaoqin; Miyata, Tatsunori; Dasarathy, Srinivasan; Rotroff, Daniel M; Nagy, Laura E.
  • Fan X; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Liu Z; Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.
  • Poulsen KL; Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.
  • Wu X; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Miyata T; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Dasarathy S; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Rotroff DM; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Nagy LE; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA.
Nutrients ; 13(5)2021 May 10.
Article in English | MEDLINE | ID: covidwho-1224082
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
2. Prognosis bad PROCESS_OF Patients
Subject
Prognosis bad
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. IMPACT gene DISRUPTS COVID-19
Subject
IMPACT gene
Predicate
DISRUPTS
Object
COVID-19
5. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
6. Alcohol consumption PREDISPOSES COVID-19
Subject
Alcohol consumption
Predicate
PREDISPOSES
Object
COVID-19
7. COVID-19 PROCESS_OF Participant
Subject
COVID-19
Predicate
PROCESS_OF
Object
Participant
8. Cessation of life NEG_PROCESS_OF Patients
Subject
Cessation of life
Predicate
NEG_PROCESS_OF
Object
Patients
9. Predisposition -- attribute NEG_ASSOCIATED_WITH COVID-19
Subject
Predisposition -- attribute
Predicate
NEG_ASSOCIATED_WITH
Object
COVID-19
10. Obesity PROCESS_OF Participant
Subject
Obesity
Predicate
PROCESS_OF
Object
Participant
11. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
12. Prognosis bad PROCESS_OF Patients
Subject
Prognosis bad
Predicate
PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. IMPACT gene DISRUPTS COVID-19
Subject
IMPACT gene
Predicate
DISRUPTS
Object
COVID-19
15. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
16. Alcohol consumption PREDISPOSES COVID-19
Subject
Alcohol consumption
Predicate
PREDISPOSES
Object
COVID-19
17. COVID-19 PROCESS_OF Participant
Subject
COVID-19
Predicate
PROCESS_OF
Object
Participant
18. Cessation of life NEG_PROCESS_OF Patients
Subject
Cessation of life
Predicate
NEG_PROCESS_OF
Object
Patients
19. Predisposition -- attribute NEG_ASSOCIATED_WITH COVID-19
Subject
Predisposition -- attribute
Predicate
NEG_ASSOCIATED_WITH
Object
COVID-19
20. Obesity PROCESS_OF Participant
Subject
Obesity
Predicate
PROCESS_OF
Object
Participant
ABSTRACT

BACKGROUND:

Acute and chronic alcohol abuse has adverse impacts on both the innate and adaptive immune response, which may result in reduced resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and promote the progression of coronavirus disease 2019 (COVID-19). However, there are no large population-based data evaluating potential causal associations between alcohol consumption and COVID-19.

METHODS:

We conducted a Mendelian randomization study using data from UK Biobank to explore the association between alcohol consumption and risk of SARS-CoV-2 infection and serious clinical outcomes in patients with COVID-19. A total of 12,937 participants aged 50-83 who tested for SARS-CoV-2 between 16 March to 27 July 2020 (12.1% tested positive) were included in the analysis. The exposure factor was alcohol consumption. Main outcomes were SARS-CoV-2 positivity and death in COVID-19 patients. We generated allele scores using three genetic variants (rs1229984 (Alcohol Dehydrogenase 1B, ADH1B), rs1260326 (Glucokinase Regulator, GCKR), and rs13107325 (Solute Carrier Family 39 Member 8, SLC39A8)) and applied the allele scores as the instrumental variables to assess the effect of alcohol consumption on outcomes. Analyses were conducted separately for white participants with and without obesity.

RESULTS:

Of the 12,937 participants, 4496 were never or infrequent drinkers and 8441 were frequent drinkers. Both logistic regression and Mendelian randomization analyses found no evidence that alcohol consumption was associated with risk of SARS-CoV-2 infection in participants either with or without obesity (All q > 0.10). However, frequent drinking, especially heavy drinking (HR = 2.07, 95%CI 1.24-3.47; q = 0.054), was associated with higher risk of death in patients with obesity and COVID-19, but not in patients without obesity. Notably, the risk of death in frequent drinkers with obesity increased slightly with the average amount of alcohol consumed weekly (All q < 0.10).

CONCLUSIONS:

Our findings suggest that alcohol consumption has adverse effects on the progression of COVID-19 in white participants with obesity, but was not associated with susceptibility to SARS-CoV-2 infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Alcohol Dehydrogenase / Alcohol Drinking / Biological Specimen Banks / Polymorphism, Single Nucleotide / Cation Transport Proteins / SARS Virus / Adaptor Proteins, Signal Transducing / COVID-19 / Obesity Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Nu13051592

Full text: Available Collection: International databases Database: MEDLINE Main subject: Alcohol Dehydrogenase / Alcohol Drinking / Biological Specimen Banks / Polymorphism, Single Nucleotide / Cation Transport Proteins / SARS Virus / Adaptor Proteins, Signal Transducing / COVID-19 / Obesity Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Nu13051592