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Clinical and Radiological Profiles of COVID-19 Patients with Neurological Symptomatology: A Comparative Study.
Aragao, Maria de Fatima Viana Vasco; Leal, Mariana de Carvalho; Andrade, Pedro Henrique Pereira; Cartaxo Filho, Ocelio Queiroga; Aragao, Lucas Vasco; Fonseca, Tatiana Moreira; Valenca, Marcelo Andrade; Leao, Maria Regina Vendas Carneiro; Aragao, Joao Pedro Vasco; Soares, Maria Lúcia; Lima, Mirelle Palmeira; Caldas, Silvio S; Valenca, Marcelo Moraes.
  • Aragao MFVV; Centro de Biociências, Anatomy Department, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Leal MC; Centro Diagnostico Multimagem, Recife 50070-450, Brazil.
  • Andrade PHP; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Cartaxo Filho OQ; Real Hospital Português de Beneficência em Pernambuco, Recife 50050-290, Brazil.
  • Aragao LV; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Fonseca TM; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Valenca MA; Endoscopy Department, Hospital 9 de Julho, São Paulo 01409-002, Brazil.
  • Leao MRVC; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Aragao JPV; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Soares ML; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • Lima MP; Faculdade de Medicina de Olinda, Olinda 53030-030, Brazil.
  • Caldas SS; Propedeutics Department, Áreas de Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Alagoas, Alagoas 57072-970, Brazil.
  • Valenca MM; Department of Morphological and Functional Organization 1, 2 and 3, Centro Universitário Cesmac, Alagoas 57051-160, Brazil.
Viruses ; 13(5)2021 05 06.
Article in English | MEDLINE | ID: covidwho-1224253
ABSTRACT
Patients with COVID-19 can require radiological examination, with chest CT being more frequent than neuro-imaging. The objective is to identify epidemiological, clinical and radiological factors considered as predictors of neurological involvement in patients with COVID-19 assessed by neuroimaging and to describe the neuroimaging findings. This retrospective study was performed with 232 consecutive confirmed COVID-19 patients, from two radiological units, which were divided into two groups (1) those who underwent a brain CT/MRI scan (n = 35) versus (2) those who did not undergo the brain CT/MRI scan, but underwent only chest CT (n = 197). There was a statistically significant difference with associations regarding the COVID-19 brain scan group for admission to ICU, greater severity of lung injuries, the use of a mechanical ventilator and sepsis. Statistical tendency was found for chronic renal failure and systemic arterial hypertension. Forty-percent of COVID-19 patients from the brain scan group were abnormal on brain CT and/or brain MRI (22.9% of the cases with bleeding or microbleeding, 8.6% with restricted diffusion lesions). One ischemic stroke case was associated with irregularity at the M1 segment of the right middle cerebral artery. There was a case of left facial nerve palsy with enhancement of the left geniculate ganglia. An analysis of the olfactory bulbs was possible in 12 brain MRIs and 100% had enhancement and/or microbleeding. In conclusion, a more severe COVID-19 disease from ICU, a more severe form of lung disease, the use of mechanical ventilator and sepsis were associated to the COVID-19 patients with neurological involvement who had undergone brain scans. Microvascular phenomenon was a frequent finding in the brain and olfactory bulbs evaluated by neuroimaging.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimaging / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2021 Document Type: Article Affiliation country: V13050845

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimaging / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2021 Document Type: Article Affiliation country: V13050845