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Impact of COVID-19 on the management of patients with thoracic cancers in a tertiary referral center.
Basse, Clémence; Daniel, Catherine; Livartowski, Alain; Beaucaire-Danel, Sophie; Girard, Nicolas.
  • Basse C; Institut Curie, Paris, France.
  • Daniel C; Institut Curie, Paris, France.
  • Livartowski A; Institut Curie, Paris, France.
  • Beaucaire-Danel S; Institut Curie, Paris, France.
  • Girard N; Institut Curie, Paris, France; Université Paris Saclay, Université Versailles Saint Quentin, Unité de Formation et de Recherche Simone Veil - Santé, Montigny le Bretonneux, France. Electronic address: nicolas.girard2@curie.fr.
Lung Cancer ; 157: 79-84, 2021 07.
Article in English | MEDLINE | ID: covidwho-1225327
Semantic information from SemMedBD (by NLM)
1. Malignant neoplasm of thorax AFFECTS COVID-19
Subject
Malignant neoplasm of thorax
Predicate
AFFECTS
Object
COVID-19
2. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
3. Malignant neoplasm of thorax PROCESS_OF Patients
Subject
Malignant neoplasm of thorax
Predicate
PROCESS_OF
Object
Patients
4. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
5. Ambulatory Care Facilities LOCATION_OF Study
Subject
Ambulatory Care Facilities
Predicate
LOCATION_OF
Object
Study
6. Malignant neoplasm of thorax AFFECTS COVID-19
Subject
Malignant neoplasm of thorax
Predicate
AFFECTS
Object
COVID-19
7. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
8. Malignant neoplasm of thorax PROCESS_OF Patients
Subject
Malignant neoplasm of thorax
Predicate
PROCESS_OF
Object
Patients
9. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
10. Ambulatory Care Facilities LOCATION_OF Study
Subject
Ambulatory Care Facilities
Predicate
LOCATION_OF
Object
Study
ABSTRACT

INTRODUCTION:

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has spread worldwide in 2020 leading the World Health Organization to declare a pandemic. Patients with thoracic cancers have been reported at higher risk to develop severe disease, and die from COVID-19. In this setting, clinical practice recommendations for the management of patients were published. We report here how these guidelines were implemented in a routine practice setting.

METHODS:

We retrospectively collected the characteristics, treatment regimen and modification, as well as COVID-19 status and death for all patients with thoracic malignancies scheduled for an appointment at Institute Curie from March 23rd to April 17th 2020.

RESULTS:

A total of 339 patients were included. Treatment strategy was modified for a total of 110 (32 %) patients because of COVID-19; these modifications were in accordance with guidelines for 92 % of patients. The majority of dose modifications were related to immune checkpoint inhibitors, for which switch to flat dosing every 4-6 weeks was made. A total of 5 (1.5 %) patients were diagnosed with COVID-19 disease, 1 of whom died from disease complication.

CONCLUSION:

Our study provides a unique insight in the decision making for patients with thoracic malignancies in the setting of COVID-19 outbreak, showing how guidelines were implemented in the clinic, and what may be optimized in the clinical practice of thoracic oncology in the future.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Thoracic Neoplasms / COVID-19 / Lung Neoplasms Subject: Thoracic Neoplasms / COVID-19 / Lung Neoplasms Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Lung Cancer Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Thoracic Neoplasms / COVID-19 / Lung Neoplasms Subject: Thoracic Neoplasms / COVID-19 / Lung Neoplasms Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Lung Cancer Clinical aspect: Etiology Year: 2021
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