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The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: A retrospective cohort study.
Hammad, Maha O; Alseoudy, Mahmoud M.
  • Hammad MO; Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: maha_osman@mans.edu.eg.
  • Alseoudy MM; Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Prim Care Diabetes ; 15(4): 713-718, 2021 08.
Article in English | MEDLINE | ID: covidwho-1225362
ABSTRACT

AIM:

This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.

METHODS:

For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression.

RESULTS:

Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO2 were significant independent predictors of mortality (P < 0.05).

CONCLUSION:

In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Diabetes Mellitus / Health Status Disparities / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Prim Care Diabetes Journal subject: Endocrinology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Diabetes Mellitus / Health Status Disparities / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Prim Care Diabetes Journal subject: Endocrinology Year: 2021 Document Type: Article