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Vitamin D status of children with paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS).
Darren, Angeline; Osman, Meissa; Masilamani, Kavitha; Habib Ali, Syed; Kanthimathinathan, Hari Krishnan; Chikermane, Ashish; Al-Abadi, Eslam; Welch, Steven B; Hackett, Scott; Scholefield, Barnaby R; Uday, Suma; Jyothish, Deepthi.
  • Darren A; Department of General Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Osman M; Department of General Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Masilamani K; Department of General Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Habib Ali S; Department of General Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Kanthimathinathan HK; Paediatric Intensive Care Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Chikermane A; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Al-Abadi E; Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Welch SB; Department of Paediatrics, Birmingham Chest Clinic and Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK.
  • Hackett S; Department of Paediatrics, Birmingham Chest Clinic and Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK.
  • Scholefield BR; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
  • Uday S; Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Jyothish D; Department of General Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Br J Nutr ; 127(6): 896-903, 2022 03 28.
Article in English | MEDLINE | ID: covidwho-1651089
Semantic information from SemMedBD (by NLM)
1. pediatric inflammatory multisystem syndrome PROCESS_OF Child
Subject
pediatric inflammatory multisystem syndrome
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PROCESS_OF
Object
Child
2. 2019 novel coronavirus COEXISTS_WITH pediatric inflammatory multisystem syndrome
Subject
2019 novel coronavirus
Predicate
COEXISTS_WITH
Object
pediatric inflammatory multisystem syndrome
3. COVID-19 PROCESS_OF Child
Subject
COVID-19
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PROCESS_OF
Object
Child
4. calcifediol TREATS pediatric multisystem inflammatory diseas
Subject
calcifediol
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TREATS
Object
pediatric multisystem inflammatory diseas
5. calcifediol TREATS Child
Subject
calcifediol
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TREATS
Object
Child
6. pediatric multisystem inflammatory diseas PROCESS_OF C0008059
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pediatric multisystem inflammatory diseas
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C0008059
7. pediatric multisystem inflammatory diseas AFFECTS C0027567
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pediatric multisystem inflammatory diseas
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C0027567
8. pediatric inflammatory multisystem syndrome PROCESS_OF Child
Subject
pediatric inflammatory multisystem syndrome
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PROCESS_OF
Object
Child
9. 2019 novel coronavirus COEXISTS_WITH pediatric inflammatory multisystem syndrome
Subject
2019 novel coronavirus
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COEXISTS_WITH
Object
pediatric inflammatory multisystem syndrome
10. COVID-19 PROCESS_OF Child
Subject
COVID-19
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PROCESS_OF
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Child
11. calcifediol TREATS pediatric multisystem inflammatory disease, COVID-19 related
Subject
calcifediol
Predicate
TREATS
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pediatric multisystem inflammatory disease, COVID-19 related
12. calcifediol TREATS Child
Subject
calcifediol
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TREATS
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Child
13. pediatric multisystem inflammatory disease, COVID-19 related PROCESS_OF Child
Subject
pediatric multisystem inflammatory disease, COVID-19 related
Predicate
PROCESS_OF
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Child
14. pediatric multisystem inflammatory disease, COVID-19 related AFFECTS African race
Subject
pediatric multisystem inflammatory disease, COVID-19 related
Predicate
AFFECTS
Object
African race
ABSTRACT
Coronavirus disease 2019 (COVID-19) has caused mild illness in children, until the emergence of the novel hyperinflammatory condition paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS). PIMS-TS is thought to be a post-SARS-CoV-2 immune dysregulation with excessive inflammatory cytokine release. We studied 25 hydroxyvitamin D (25OHD) concentrations in children with PIMS-TS, admitted to a tertiary paediatric hospital in the UK, due to its postulated role in cytokine regulation and immune response. Eighteen children (median (range) age 8·9 (0·3-14·6) years, male = 10) met the case definition. The majority were of Black, Asian and Minority Ethnic (BAME) origin (89 %, 16/18). Positive SARS-CoV-2 IgG antibodies were present in 94 % (17/18) and RNA by PCR in 6 % (1/18). Seventy-eight percentage of the cohort were vitamin D deficient (< 30 nmol/l). The mean 25OHD concentration was significantly lower when compared with the population mean from the 2015/16 National Diet and Nutrition Survey (children aged 4-10 years) (24 v. 54 nmol/l (95 % CI -38·6, -19·7); P < 0·001). The paediatric intensive care unit (PICU) group had lower mean 25OHD concentrations compared with the non-PICU group, but this was not statistically significant (19·5 v. 31·9 nmol/l; P = 0·11). The higher susceptibility of BAME children to PIMS-TS and also vitamin D deficiency merits contemplation. Whilst any link between vitamin D deficiency and the severity of COVID-19 and related conditions including PIMS-TS requires further evidence, public health measures to improve vitamin D status of the UK BAME population have been long overdue.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Risk factors Limits: Child / Child, preschool / Humans / Male Language: English Journal: Br J Nutr Year: 2022 Document Type: Article Affiliation country: S0007114521001562

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Risk factors Limits: Child / Child, preschool / Humans / Male Language: English Journal: Br J Nutr Year: 2022 Document Type: Article Affiliation country: S0007114521001562