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Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in Intercollegiate Athletics Not Fully Mitigated With Daily Antigen Testing.
Moreno, Gage K; Braun, Katarina M; Pray, Ian W; Segaloff, Hannah E; Lim, Ailam; Poulsen, Keith; Meiman, Jonathan; Borcher, James; Westergaard, Ryan P; Moll, Michael K; Friedrich, Thomas C; O'Connor, David H.
  • Moreno GK; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Braun KM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Pray IW; Wisconsin Department of Health Services, Madison, Wisconsin, USA.
  • Segaloff HE; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lim A; Wisconsin Department of Health Services, Madison, Wisconsin, USA.
  • Poulsen K; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Meiman J; Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Borcher J; Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Westergaard RP; Wisconsin Department of Health Services, Madison, Wisconsin, USA.
  • Moll MK; Department of Family Medicine, Division of Sports Medicine, Ohio State University, Columbus Ohio, USA.
  • Friedrich TC; Wisconsin Department of Health Services, Madison, Wisconsin, USA.
  • O'Connor DH; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Clin Infect Dis ; 73(Suppl 1): S45-S53, 2021 07 15.
Article in English | MEDLINE | ID: covidwho-1225623
Semantic information from SemMedBD (by NLM)
1. Confirmed case PROCESS_OF Athletes
Subject
Confirmed case
Predicate
PROCESS_OF
Object
Athletes
2. Antigens ADMINISTERED_TO Athletes
Subject
Antigens
Predicate
ADMINISTERED_TO
Object
Athletes
3. Virus PROCESS_OF Community
Subject
Virus
Predicate
PROCESS_OF
Object
Community
4. Team LOCATION_OF DNA Sequence
Subject
Team
Predicate
LOCATION_OF
Object
DNA Sequence
5. Confirmed case PROCESS_OF Athletes
Subject
Confirmed case
Predicate
PROCESS_OF
Object
Athletes
6. Antigens ADMINISTERED_TO Athletes
Subject
Antigens
Predicate
ADMINISTERED_TO
Object
Athletes
7. Virus PROCESS_OF Community
Subject
Virus
Predicate
PROCESS_OF
Object
Community
8. Team LOCATION_OF DNA Sequence
Subject
Team
Predicate
LOCATION_OF
Object
DNA Sequence
ABSTRACT

BACKGROUND:

High-frequency, rapid-turnaround severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing continues to be proposed as a way of efficiently identifying and mitigating transmission in congregate settings. However, 2 SARS-CoV-2 outbreaks occurred among intercollegiate university athletic programs during the fall 2020 semester, despite mandatory directly observed daily antigen testing.

METHODS:

During the fall 2020 semester, athletes and staff in both programs were tested daily using Quidel's Sofia SARS Antigen Fluorescent Immunoassay, with positive antigen results requiring confirmatory testing with real-time reverse-transcription polymerase chain reaction. We used genomic sequencing to investigate transmission dynamics in these 2 outbreaks.

RESULTS:

In the first outbreak, 32 confirmed cases occurred within a university athletics program after the index patient attended a meeting while infectious, despite a negative antigen test on the day of the meeting. Among isolates sequenced from that outbreak, 24 (92%) of 26 were closely related, suggesting sustained transmission following an initial introduction event. In the second outbreak, 12 confirmed cases occurred among athletes from 2 university programs that faced each other in an athletic competition, despite receipt of negative antigen test results on the day of the competition. Sequences from both teams were closely related and distinct from viruses circulating in the community for team 1, suggesting transmission during intercollegiate competition in the community for team 2.

CONCLUSIONS:

These findings suggest that antigen testing alone, even when mandated and directly observed, may not be sufficient as an intervention to prevent SARS-CoV-2 outbreaks in congregate settings, and they highlight the importance of vaccination to prevent SARS-CoV-2 outbreak in congregate settings.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Sports / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sports / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid