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Can laboratory findings predict pulmonary involvement in children with COVID-19 infection?
Böncüoglu, Elif; Coskun, Mehmet; Kiymet, Elif; Öztürk Atasoy, Tülay; Sahinkaya, Sahika; Cem, Ela; Düzgöl, Mine; Yilmaz Çelebi, Miray; Akaslan Kara, Aybüke; Arikan, Kamile Ö; Bayram, Nuri; Devrim, Ilker.
  • Böncüoglu E; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Coskun M; Department of Radiology, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Kiymet E; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Öztürk Atasoy T; Department of Radiology, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Sahinkaya S; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Cem E; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Düzgöl M; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Yilmaz Çelebi M; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Akaslan Kara A; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Arikan KÖ; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Bayram N; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
  • Devrim I; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
Pediatr Pulmonol ; 56(8): 2489-2494, 2021 08.
Article in English | MEDLINE | ID: covidwho-1226201
ABSTRACT

BACKGROUND:

Studies investigating clinical and imaging findings of coronavirus disease 2019 (COVID-19) pneumonia and predictors for lung injury mostly focus on adults. In this study, we aimed to evaluate the role of laboratory findings in predicting lung involvement in children with COVID-19.

METHODS:

Children with COVID-19 confirmed by reverse-transcription polymerase chain reaction or COVID-19 IgM and who underwent chest computed tomography (CT) scans were reviewed retrospectively. Admission absolute neutrophil count (ANC), absolute lymphocyte count (ALC), ANC/ALC ratio, platelet count, D-dimer, fibrinogen, ferritin, procalcitonin, C-reactive protein (CRP), and lactate dehydrogenase levels were compared in patients with normal and abnormal CT scans.

RESULTS:

A total of 101 children were included. Among the patients, 68 (67.3%) had normal CT scans, and 33 (32.7%) had pulmonary involvement. The median CRP, ferritin, and fibrinogen levels were significantly higher in children with abnormal CT findings. The model of binary logistic regression based on the presence of cough, shortness of breath, fibrinogen, ferritin, and CRP levels showed that the possibility of having abnormal CT was 1.021 times more likely for every one unit increase in fibrinogen levels.

CONCLUSION:

Fibrinogen might be useful to predict pulmonary involvement of COVID-19 in children. Restricting radiological imaging to patients with significant symptoms and high fibrinogen levels might be helpful in children with COVID-19 infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Laboratories / Lung Diseases Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Child / Female / Humans / Male Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Ppul.25452

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Laboratories / Lung Diseases Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Child / Female / Humans / Male Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Ppul.25452