ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome.
Neurol Sci
; 42(10): 4293-4296, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1226223
ABSTRACT
INTRODUCTION:
Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae's family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to 36.4%. Acute disseminated encephalomyelitis (ADEM) has been recently included among the potential complications of Sars-Cov2 infection. The available data regarding pediatric patient show only one case. CASE REPORT We present a case regarding a 6-year-old patient suffering from Fisher-Evans syndrome who was given sirolimus and thalidomide therapy. After 10 days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of acute disseminated encephalomyelitis. His clinical course was favorable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture.CONCLUSIONS:
According to our knowledge, this is the second case of an acute disseminated encephalomyelitis following SARS-CoV-2 infection in a pediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher-Evans syndrome has probably contributed to a favorable evolution of ADEM, in contrast to other case described in the literature.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Encephalomyelitis, Acute Disseminated
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Child
/
Humans
/
Male
Language:
English
Journal:
Neurol Sci
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
S10072-021-05311-1
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