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Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown.
Breyer, Marie-Kathrin; Breyer-Kohansal, Robab; Hartl, Sylvia; Kundi, Michael; Weseslindtner, Lukas; Stiasny, Karin; Puchhammer-Stöckl, Elisabeth; Schrott, Andrea; Födinger, Manuela; Binder, Michael; Fiedler, Markus; Wouters, Emiel F M; Burghuber, Otto C.
  • Breyer MK; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria. marie.breyer@gmx.at.
  • Breyer-Kohansal R; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria. marie.breyer@gmx.at.
  • Hartl S; Ludwig Boltzmann Institute for Lung Health, The Austrian LEAD Study, Klink Penzing, Gebäude G, 2. Stock, Sanatoriumstrasse 2, 1140, Vienna, Austria. marie.breyer@gmx.at.
  • Kundi M; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.
  • Weseslindtner L; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
  • Stiasny K; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.
  • Puchhammer-Stöckl E; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
  • Schrott A; Sigmund Freud University, Faculty of Medicine, Vienna, Austria.
  • Födinger M; Center for Public Health, Medical University of Vienna, Vienna, Austria.
  • Binder M; Center for Virology, Medical University of Vienna, Vienna, Austria.
  • Fiedler M; Center for Virology, Medical University of Vienna, Vienna, Austria.
  • Wouters EFM; Center for Virology, Medical University of Vienna, Vienna, Austria.
  • Burghuber OC; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
Sci Rep ; 11(1): 10158, 2021 05 12.
Article in English | MEDLINE | ID: covidwho-1226443
ABSTRACT
We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, were invited along with their household members (April 20th to May20th 2020). Sera were analyzed using anti-SARS-CoV-2 immunoassay including a neutralization test as a confirmatory assay. A total of 12,419 individuals participated (5984 LEAD participants; 6435 household members), 163 (1.31%; 59 LEAD cohort members) of whom were SARS-CoV-2 antibody positive. The estimated number of COVID-19 cases projected from our findings by age and sex for Vienna was 21,504 (1.13%). Cumulative number of positively tested cases in Vienna until May 20th 2020 was 3020, hence 7.1 times (95% confidence interval 5.5-9.1) lower than projected. Relative risk (RR) of seropositivity by age was highest for children aged 6-9 years [RR compared to age group 20-49 1.21 (CI 0.37-4.01)], lowest for ≥ 65 years [RR 0.47 (CI 0.21-1.03)]. Half of the positive individuals developed no or mild symptoms. In a multivariate analysis, taste and smell disturbances were most strongly related to SARS-CoV-2 positivity. Infection probability within households with one confirmed SARS-CoV-2-specific antibody-positive person was 31%. Although seroprevalence was very low (1.13%) for a central European capital city, due to an early governmental lockdown, SARS-CoV-2 infections were more prevalent than officially reported polymerase chain reaction-positive cases. Of note, seroprevalence was highest in young children. Half of SARS-CoV-2 antibody-positive subjects had no or only mild symptoms. Taste and smell disturbances were most prominent, possibly guiding clinicians in diagnosing SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-89711-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-89711-5