De Novo Focal and Segmental Glomerulosclerosis After COVID-19 in a Patient With a Transplanted Kidney From a Donor With a High-risk APOL1 Variant.
Transplantation
; 105(1): 206-211, 2021 01 01.
Article
in English
| MEDLINE | ID: covidwho-1226601
ABSTRACT
BACKGROUND:
There is compelling evidence that renal complications in a native kidney are a major concern in patients infected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). The spectrum of renal lesions observed on renal grafts in this context remains to be determined.METHODS:
We report the case of a renal transplant recipient with non-severe COVID-19, who subsequently developed nephrotic syndrome associated with acute renal injury.RESULTS:
Renal biopsy demonstrated focal and segmental glomerulosclerosis lesions classified as not otherwise specified histological variant. Genotyping for 2 risk alleles of the apolipoprotein L1 gene demonstrated that the donor was homozygous for the G2/G2 genotype.CONCLUSIONS:
In renal transplant patients receiving kidneys from donors with high-risk apolipoprotein L1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tissue Donors
/
Glomerulosclerosis, Focal Segmental
/
Kidney Transplantation
/
Apolipoprotein L1
/
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Long Covid
/
Variants
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Transplantation
Year:
2021
Document Type:
Article
Affiliation country:
Tp.0000000000003432
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