Creutzfeldt-Jakob disease as a cause of dementia.
BMJ Case Rep
; 14(5)2021 May 11.
Article
in English
| MEDLINE | ID: covidwho-1226742
ABSTRACT
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder belonging to the family of transmissible spongiform encephalopathies. The disease is believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. Our patient is an 84-year-old Caucasian man who presented to the geriatric clinic for evaluation of short-term memory loss and decreased concentration which started 3 months prior to initial evaluation. Rapid progression of dementia demonstrated by severe impairment in tasks with a predominantly visual component, including visual scanning, perceptual reasoning and visual spatial processing. Diagnosis of CJD was determined by characteristic ribboning on brain MRI as well as notable real-time quaking-induced conversion on cerebrospinal fluid.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Creutzfeldt-Jakob Syndrome
/
Prion Diseases
Type of study:
Case report
/
Diagnostic study
/
Experimental Studies
Topics:
Long Covid
/
Variants
Limits:
Aged
/
Humans
/
Male
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Bcr-2020-240020
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