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Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection.
Ottaiano, Alessandro; Scala, Stefania; D'Alterio, Crescenzo; Trotta, Annamaria; Bello, Annamaria; Rea, Giuseppina; Picone, Carmine; Santorsola, Mariachiara; Petrillo, Antonella; Nasti, Guglielmo.
  • Ottaiano A; SSD-Innovative Therapies for Abdominal Metastases, Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' via M. Semmola, Naples 80131, Italy.
  • Scala S; Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • D'Alterio C; Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Trotta A; Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Bello A; Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Rea G; Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Picone C; Department of Radiology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Santorsola M; SSD-Innovative Therapies for Abdominal Metastases, Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Petrillo A; Department of Radiology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
  • Nasti G; SSD-Innovative Therapies for Abdominal Metastases, Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
Ther Adv Med Oncol ; 13: 17588359211011455, 2021.
Article in English | MEDLINE | ID: covidwho-1226850
ABSTRACT
Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Ther Adv Med Oncol Year: 2021 Document Type: Article Affiliation country: 17588359211011455

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Ther Adv Med Oncol Year: 2021 Document Type: Article Affiliation country: 17588359211011455