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A review of monoclonal antibodies in COVID-19: Role in immunotherapy, vaccine development and viral detection.
Tabll, Ashraf A; Shahein, Yasser E; Omran, Mohamed M; Elnakib, Mostafa M; Ragheb, Ameera A; Amer, Khaled E.
  • Tabll AA; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
  • Shahein YE; Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt.
  • Omran MM; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
  • Elnakib MM; Molecular Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt.
  • Ragheb AA; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
  • Amer KE; Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
Hum Antibodies ; 29(3): 179-191, 2021.
Article in English | MEDLINE | ID: covidwho-1226968
ABSTRACT
The harmful COVID-19 pandemic caused by the SARS-CoV-2 coronavirus imposes the scientific community to develop or find conventional curative drugs, protective vaccines, or passive immune strategies rapidly and efficiently. Passive immunity is based on recovering hyper-immune plasma from convalescent patients, or monoclonal antibodies with elevated titer of neutralizing antibodies with high antiviral activity, that have potential for both treatment and prevention. In this review, we focused on researching the potentiality of monoclonal antibodies for the prevention and treatment of COVID-19 infection. Our research review includes antibody-based immunotherapy, using human monoclonal antibodies targeting SARS-CoV-2 viral protein regions, specifically the spike protein regions, and using hyper-immune plasma from convalescent COVID-19 patients, in which monoclonal antibodies act as immunotherapy for the cytokine storm syndrome associated with the COVID-19 infection. In addition, we will demonstrate the role of the monoclonal antibodies in the development of candidate vaccines for SARS-CoV-2. Moreover, the recent progress of the diagnostic mouse monoclonal antibodies' role will be highlighted, as an accurate and rapid diagnostic assay, in the antigen detection of SARS-CoV-2. In brief, the monoclonal antibodies are the potential counter measures that may control SARS-CoV-2, which causes COVID-19 disease, through immunotherapy and vaccine development, as well as viral detection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Passive / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Drug Treatment / Antibodies, Monoclonal Topics: Vaccines Limits: Humans Language: English Journal: Hum Antibodies Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Hab-200441

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Passive / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Drug Treatment / Antibodies, Monoclonal Topics: Vaccines Limits: Humans Language: English Journal: Hum Antibodies Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Hab-200441