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Assessment of the Association of COPD and Asthma with In-Hospital Mortality in Patients with COVID-19. A Systematic Review, Meta-Analysis, and Meta-Regression Analysis.
Reyes, Felix M; Hache-Marliere, Manuel; Karamanis, Dimitris; Berto, Cesar G; Estrada, Rodolfo; Langston, Matthew; Ntaios, George; Gulani, Perminder; Shah, Chirag D; Palaiodimos, Leonidas.
  • Reyes FM; Division of Pulmonary Medicine, Montefiore Medical Center, Bronx, NY 10461, USA.
  • Hache-Marliere M; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Karamanis D; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Berto CG; Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA.
  • Estrada R; Department of Economics, University of Piraeus, 18534 Attica, Greece.
  • Langston M; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Ntaios G; Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA.
  • Gulani P; Division of Pulmonary Diseases and Critical Care Medicine, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.
  • Shah CD; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Palaiodimos L; Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA.
J Clin Med ; 10(10)2021 May 13.
Article in English | MEDLINE | ID: covidwho-1227036
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Asthma PROCESS_OF Patients
Subject
Asthma
Predicate
PROCESS_OF
Object
Patients
3. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
Patients
4. Scientific Study DIAGNOSES COVID-19
Subject
Scientific Study
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DIAGNOSES
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COVID-19
5. CD69 protei ASSOCIATED_WITH C0004096
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CD69 protei
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ASSOCIATED_WITH
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C0004096
6. CD69 protei ASSOCIATED_WITH C0024117
Subject
CD69 protei
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ASSOCIATED_WITH
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C0024117
7. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
8. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF hospitalized patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
hospitalized patients
9. Chronic Obstructive Airway Disease PROCESS_OF hospitalized patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
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hospitalized patients
10. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
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Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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Patients
12. Asthma PROCESS_OF Patients
Subject
Asthma
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PROCESS_OF
Object
Patients
13. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
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Patients
14. Scientific Study DIAGNOSES COVID-19
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COVID-19
15. CD69 protein, human|CD69 ASSOCIATED_WITH Asthma
Subject
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ASSOCIATED_WITH
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Asthma
16. CD69 protein, human|CD69 ASSOCIATED_WITH Chronic Obstructive Airway Disease
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CD69 protein, human|CD69
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ASSOCIATED_WITH
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Chronic Obstructive Airway Disease
17. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
18. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF hospitalized patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
hospitalized patients
19. Chronic Obstructive Airway Disease PROCESS_OF hospitalized patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
hospitalized patients
20. Cessation of life PROCESS_OF Patients
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Cessation of life
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PROCESS_OF
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Patients
ABSTRACT
Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in coronavirus disease 2019 (COVID-19). The aim of this study was to explore the association of COPD and asthma with in-hospital mortality in patients with COVID-19 by systematically reviewing and synthesizing with a meta-analysis the available observational studies. MEDLINE, Scopus, and medRxiv databases were reviewed. A random-effects model meta-analysis was used, and I-square was utilized to assess for heterogeneity. In-hospital mortality was defined as the primary endpoint. Sensitivity and meta-regression analyses were performed. Thirty studies with 21,309 patients were included in this meta-analysis (1465 with COPD and 633 with asthma). Hospitalized COVID-19 patients with COPD had higher risk of death compared to those without COPD (OR 2.29; 95% CI 1.79-2.93; I2 59.6%). No significant difference in in-hospital mortality was seen in patients with and without asthma (OR 0.87; 95% CI 0.68-1.10; I2 0.0%). The likelihood of death was significantly higher in patients with COPD that were hospitalized with COVID-19 compared to patients without COPD. Further studies are needed to assess whether this association is independent or not. No significant difference was demonstrated in COVID-19-related mortality between patients with and without asthma.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10102087

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10102087