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First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome.
Araújo, Naiana Mota; Ferreira, Lis Campos; Dantas, Débora Paraíso; Silva, Denison Santos; Dos Santos, Cliomar Alves; Cipolotti, Rosana; Martins-Filho, Paulo Ricardo.
  • Araújo NM; From the Medical Residence Program, Fundação de Beneficência Hospital de Cirurgia.
  • Ferreira LC; Neuroimmunology Clinic, Federal University of Sergipe.
  • Dantas DP; Department of Medicine, Tiradentes University, Aracaju.
  • Silva DS; Health Sciences Graduate Program, Federal University of Sergipe.
  • Dos Santos CA; Department of Medicine, Tiradentes University, Aracaju.
  • Cipolotti R; Department of Medicine, Tiradentes University, Aracaju.
  • Martins-Filho PR; Health Foundation Parreiras Horta, Central Laboratory of Public Health (LACEN/SE), Sergipe State Health Secretariat.
Pediatr Infect Dis J ; 40(7): e274-e276, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1228550
Semantic information from SemMedBD (by NLM)
1. Detection TREATS Guillain-Barre Syndrome
Subject
Detection
Predicate
TREATS
Object
Guillain-Barre Syndrome
2. Guillain-Barre Syndrome PROCESS_OF Child
Subject
Guillain-Barre Syndrome
Predicate
PROCESS_OF
Object
Child
3. Detection TREATS Child
Subject
Detection
Predicate
TREATS
Object
Child
4. Body tissue LOCATION_OF Immune response
Subject
Body tissue
Predicate
LOCATION_OF
Object
Immune response
5. Guillain-Barre Syndrome COEXISTS_WITH COVID-19
Subject
Guillain-Barre Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
6. Peripheral Nerves LOCATION_OF Inflammation
Subject
Peripheral Nerves
Predicate
LOCATION_OF
Object
Inflammation
7. Circumferential Supracrestal Fiberotomy CAUSES Inflammation
Subject
Circumferential Supracrestal Fiberotomy
Predicate
CAUSES
Object
Inflammation
8. Detection TREATS Guillain-Barre Syndrome
Subject
Detection
Predicate
TREATS
Object
Guillain-Barre Syndrome
9. Guillain-Barre Syndrome PROCESS_OF Child
Subject
Guillain-Barre Syndrome
Predicate
PROCESS_OF
Object
Child
10. Detection TREATS Child
Subject
Detection
Predicate
TREATS
Object
Child
11. Body tissue LOCATION_OF Immune response
Subject
Body tissue
Predicate
LOCATION_OF
Object
Immune response
12. Guillain-Barre Syndrome COEXISTS_WITH COVID-19
Subject
Guillain-Barre Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
13. Peripheral Nerves LOCATION_OF Inflammation
Subject
Peripheral Nerves
Predicate
LOCATION_OF
Object
Inflammation
14. Circumferential Supracrestal Fiberotomy CAUSES Inflammation
Subject
Circumferential Supracrestal Fiberotomy
Predicate
CAUSES
Object
Inflammation
ABSTRACT
Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: RNA, Viral / Guillain-Barre Syndrome / COVID-19 Subject: RNA, Viral / Guillain-Barre Syndrome / COVID-19 Type of study: Case report / Diagnostic study Language: English Journal: Pediatr Infect Dis J Clinical aspect: Diagnosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: RNA, Viral / Guillain-Barre Syndrome / COVID-19 Subject: RNA, Viral / Guillain-Barre Syndrome / COVID-19 Type of study: Case report / Diagnostic study Language: English Journal: Pediatr Infect Dis J Clinical aspect: Diagnosis Year: 2021
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