Your browser doesn't support javascript.
Outcomes of COVID-19 in solid organ transplant recipients: A matched cohort study.
Pereira, Marcus R; Arcasoy, Selim; Farr, Maryjane A; Mohan, Sumit; Emond, Jean C; Tsapepas, Demetra S; Shi, Qiuhu; Purpura, Lawrence; Uhlemann, Anne-Catrin; Zucker, Jason; Verna, Elizabeth C.
  • Pereira MR; Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Arcasoy S; Lung Transplant Program, Division of Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Farr MA; Department of Medicine, Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Mohan S; Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Emond JC; Columbia University College of Physicians and Surgeons, The Columbia University Renal Epidemiology (CURE) Group, New York, NY, USA.
  • Tsapepas DS; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Shi Q; Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Purpura L; Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Uhlemann AC; Department of Public Health, School of Health Sciences and Practice, New York Medical College, New York, NY, USA.
  • Zucker J; Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Verna EC; Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Transpl Infect Dis ; 23(4): e13637, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1228844
ABSTRACT
Whether solid organ transplant (SOT) recipients are at increased risk of poor outcomes due to COVID-19 in comparison to the general population remains uncertain. In this study, we compared outcomes of SOT recipients and non-SOT patients hospitalized with COVID-19 in a propensity score matched analysis based on age, race, ethnicity, BMI, diabetes, and hypertension. After propensity matching, 117 SOT recipients and 350 non-SOT patients were evaluated. The median age of SOT recipients was 61 years, with a median time from transplant of 5.68 years. The most common transplanted organs were kidney (48%), followed by lung (21%), heart (19%), and liver (10%). Overall, SOT recipients were more likely to receive COVID-19 specific therapies and to require ICU admission. However, mortality (23.08% in SOT recipients vs. 23.14% in controls, P = .21) and highest level of supplemental oxygen (P = .32) required during hospitalization did not significantly differ between groups. In this propensity matched cohort study, SOT recipients hospitalized with COVID-19 had similar overall outcomes as non-SOT recipients, suggesting that chronic immunosuppression may not be an independent risk factor for poor outcomes in COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Tid.13637

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Tid.13637