Nasal expression of SARS-CoV-2 entry receptors in newborns.
Arch Dis Child Fetal Neonatal Ed
; 107(1): 95-97, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1228860
ABSTRACT
BACKGROUND:
SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal expression of four SARS-CoV-2 entry receptors between term and preterm newborns and adults.METHODS:
Nasal scrape samples were obtained from 28 newborns (17 term and 11 preterm) and 10 adults. Reverse-transcription quantitative PCR was used to measure mRNA expression of ACE2, transmembrane serine protease 2 (TMPRSS2), neuropilin 1 (NRP1) and neuropilin 2 (NRP2) and insulin-like growth factor 1 receptor (IGF1R).RESULTS:
Expression levels of ACE2, TMPRSS2, NRP1 and NRP2 were lower in term and preterm newborns and IGF1R lower in term newborns compared with adults (p<0.05).CONCLUSIONS:
Both term and preterm newborns, compared with adults, have lower expression of SARS-CoV-2 entry receptors in nasal epithelium.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Nasal Mucosa
Limits:
Adult
/
Humans
/
Middle aged
/
Infant, Newborn
Language:
English
Journal:
Arch Dis Child Fetal Neonatal Ed
Journal subject:
Pediatrics
/
Perinatology
Year:
2022
Document Type:
Article
Affiliation country:
Archdischild-2020-321334
Similar
MEDLINE
...
LILACS
LIS