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Frequency of Autoantibody-Negative Type 1 Diabetes in Children, Adolescents, and Young Adults During the First Wave of the COVID-19 Pandemic in Germany.
Kamrath, Clemens; Rosenbauer, Joachim; Tittel, Sascha R; Warncke, Katharina; Hirtz, Raphael; Denzer, Christian; Dost, Axel; Neu, Andreas; Pacaud, Danièle; Holl, Reinhard W.
  • Kamrath C; Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany clemens.kamrath@paediat.med.uni-giessen.de.
  • Rosenbauer J; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany.
  • Tittel SR; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
  • Warncke K; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
  • Hirtz R; Institute of Epidemiology and Medical Biometry, Zentralinstitut für Biomedizinische Technik, Ulm University, Ulm, Germany.
  • Denzer C; Department of Pediatrics, Technical University of Munich School of Medicine, Munich, Germany.
  • Dost A; Department of Pediatrics II, University Hospital Essen, Essen, Germany.
  • Neu A; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
  • Pacaud D; Department of Pediatrics, University Hospital Jena, Jena, Germany.
  • Holl RW; University Children's Hospital Tuebingen, Tuebingen, Germany.
Diabetes Care ; 44(7): 1540-1546, 2021 07.
Article in English | MEDLINE | ID: covidwho-1229141
Semantic information from SemMedBD (by NLM)
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ABSTRACT

OBJECTIVE:

The aim of this study was to investigate the frequency of newly diagnosed type 1 diabetes without evidence of autoimmunity and the respective frequencies of ketoacidosis in children, adolescents, and young adults during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with the previous decade. RESEARCH DESIGN AND

METHODS:

Based on data from the German Diabetes Prospective Follow-up Registry (DPV), we compared data from 715 children, adolescents, and young adults, newly diagnosed with type 1 diabetes during the COVID-19 pandemic in Germany between 1 March and 30 June 2020, with data from 5,428 children, adolescents, and young adults of the same periods from 2011 to 2019. Adjusted differences and relative risks (RRs) of negative ß-cell autoantibody test results and diabetic ketoacidosis were estimated using multivariable log-binomial regression analysis. An upper noninferiority test (margin 1%) was applied to evaluate whether the autoantibody-negativity rate in 2020 was not higher than that in 2011 to 2019.

RESULTS:

The estimated frequencies of autoantibody negativity in 2020 and 2011-2019 were 6.6% (95% CI 5.1-8.4) and 7.2% (95% CI 6.5-8.0), respectively, with an absolute difference of -0.68% (90% CI -2.07 to 0.71; P upper noninferiority = 0.023). The increase of the estimated frequency of diabetic ketoacidosis during the COVID-19 pandemic was similar between autoantibody-negative and -positive type 1 diabetes (adjusted RRs 1.28 [95% CI 0.80-2.05] and 1.57 [1.41-1.75], respectively).

CONCLUSIONS:

This study found no evidence that the COVID-19 pandemic leads to a significantly increased number of new cases with autoantibody-negative type 1 diabetes in children, adolescents, and young adults. In addition, autoantibody-negative type 1 diabetes showed no particular susceptibility to ketoacidosis, neither before nor during the pandemic.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetic Ketoacidosis / Diabetes Mellitus, Type 1 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Child / Humans / Young adult Country/Region as subject: Europa Language: English Journal: Diabetes Care Year: 2021 Document Type: Article Affiliation country: Dc20-2791

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetic Ketoacidosis / Diabetes Mellitus, Type 1 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Child / Humans / Young adult Country/Region as subject: Europa Language: English Journal: Diabetes Care Year: 2021 Document Type: Article Affiliation country: Dc20-2791