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The Mechanisms and Animal Models of SARS-CoV-2 Infection.
Jia, Wenrui; Wang, Juan; Sun, Bao; Zhou, Jiecan; Shi, Yamin; Zhou, Zheng.
  • Jia W; Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Wang J; Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Sun B; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Zhou J; Institute of Clinical Medicine, The First Affiliated Hospital, University of South China, Hengyang, China.
  • Shi Y; Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Zhou Z; Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Cell Dev Biol ; 9: 578825, 2021.
Article in English | MEDLINE | ID: covidwho-1229166
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has aroused great public health concern worldwide. Currently, COVID-19 epidemic is spreading in many countries and regions around the world. However, the study of SARS-CoV-2 is still in its infancy, and there is no specific therapeutics. Here, we summarize the genomic characteristics of SARS-CoV-2. In addition, we focus on the mechanisms of SARS-CoV-2 infection, including the roles of angiotensin converting enzyme II (ACE2) in cell entry, COVID-19 susceptibility and COVID-19 symptoms, as well as immunopathology such as antibody responses, lymphocyte dysregulation, and cytokine storm. Finally, we introduce the research progress of animal models of COVID-19, aiming at a better understanding of the pathogenesis of COVID-19 and providing new ideas for the treatment of this contagious disease.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Cell Dev Biol Year: 2021 Document Type: Article Affiliation country: Fcell.2021.578825

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Cell Dev Biol Year: 2021 Document Type: Article Affiliation country: Fcell.2021.578825