Diagnostic value of the serum levels of high-sensitivity c-reactive protein,wbc, lymghocyte and neutrophil counts in COVID-19

ABSTRACT

Objective To investigate the diagnostic value of the count of serum hypersensitive C-reactive protein (serum hs-CRP) and white blood cell (WBC), lymphocyte (LY) and neutrophil (NT) in coronavirus disease 2019 (COVID-19). Methods Seventy-two patients of pulmonary infection from June to August 2020 were divided into the experimental group (36 cases) and bacterial group (36 cases) according to the infection pathogen, and 30 healthy people were set as the control group. The serum hs-CRP,WBC,LY and NT were measured and compared among three groups, and the sensitivity, specificity and receiver operating characteristic (ROC) curves of four indexes were calculated and plotted. Results The differences of the serum hs-CRP,WBC,LY and NT among three groups were statistically significant (P<0.01). When the combination of four indicators was used to diagnose the COVID-19, the area under the ROC curve of the combination were 0.994, and their sensitivity (100%) and specificity (94.4%) were the highest. Conclusions The serum hs-CRP,WBC,LY and NT have certain diagnostic value in COVID-19. Moreover, the sensitivity and specificity of the combination of four indicators are higher.